| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Hayashi Yuki (日) (読)
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| 2. | 九十九 伸一 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 3. | 塩田 洋
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| 4. | 岸原 健二
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| 5. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| ○題名 (必須): | □ | (英) Antigen-Specific T Cell Repertoire Modification of CD4+CD25+ Regulatory T Cells (日)
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| ○要約 (任意): | □ | (英) T cell immune responses are regulated by the interplay between effector and suppressor T cells. Immunization with Ag leads to the selective expansion and survival of effector CD4(+) T cells with high affinity TCR against the Ag and MHC. However, it is not known if CD4(+)CD25(+) regulatory T cells (T(reg)) recognize the same Ag as effector T cells or whether Ag-specific TCR repertoire modification occurs in T(reg). In this study, we demonstrate that after a primary Ag challenge, T(reg) proliferate and TCR repertoire modification is observed although both of these responses were lower than those in conventional T cells. The repertoire modification of Ag-specific T(reg) after primary Ag challenge augmented the total suppressive function of T(reg) against TCR repertoire modification but not against the proliferation of memory CD4(+) T cells. These results reveal that T cell repertoire modification against a non-self Ag occurs in T(reg), which would be crucial for limiting excess primary and memory CD4(+) T cell responses. In addition, these studies provide evidence that manipulation of Ag-specific T(reg) is an ideal strategy for the clinical use of T(reg). (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antigen Presentation (日) (読)
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| 3. | (英) Antigens (日) (読)
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| 4. | (英) CD4-Positive T-Lymphocytes (日) (読)
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| 5. | 細胞分化 (cell differentiation)
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| 6. | 細胞分裂 (cell division)
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| 7. | (英) Cells, Cultured (日) (読)
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| 8. | (英) Columbidae (日) (読)
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| 9. | (英) Complementarity Determining Regions (日) (読)
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| 10. | (英) Cytochromes c (日) (読)
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| 11. | (英) Epitopes, T-Lymphocyte (日) (読)
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| 12. | (英) Immunization, Secondary (日) (読)
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| 13. | (英) Immunologic Memory (日) (読)
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| 14. | (英) Lymphocyte Count (日) (読)
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| 15. | (英) Mice (日) (読)
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| 16. | (英) Mice, Inbred A (日) (読)
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| 17. | (英) Mice, Inbred C57BL (日) (読)
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| 18. | (英) Receptors, Antigen, T-Cell, alpha-beta (日) (読)
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| 19. | (英) T-Lymphocytes, Regulatory (日) (読)
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| ○発行所 (推奨): | □ | The American Association of Immunologists
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| ○誌名 (必須): | □ | The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
| ○ISSN (任意): | □ | 0022-1767
ISSN: 0022-1767
(pISSN: 0022-1767, eISSN: 1550-6606) Title: Journal of immunology (Baltimore, Md. : 1950)Title(ISO): J ImmunolPublisher: American Association of Immunologists (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 172
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| ○号 (必須): | □ | 9
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| ○頁 (必須): | □ | 5240 5248
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2004年 5月 1日 (平成 16年 5月 1日)
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| ○URL (任意): |
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| ○PMID (任意): | □ | 15100262 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000221012300014
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Immunology and Parasitology, School of Medicine, University of Tokushima, Kuramoto, Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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