| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 塩田 洋
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| ○学籍番号 (推奨): |
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| 2. | (英) Nitta Keiko (日) (読) にった けいこ
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 3. | 内藤 毅
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 4. | (英) Mimura Yasuo (日) (読) みむら やすお
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 5. | (英) Maruyama Tokumi (日) (読) まるやま とくみ
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Clinical evaluation of carbocyclic oxetanocin G eyedrops in the treatment of herpes simplex corneal ulcers (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Acyclovir (ACV) ophthalmic ointment is effective in the treatment of herpetic keratitis. However, when applied, the ointment has an unpleasant feeling and some cases are resistant to ACV. A new antiviral compound, carbocyclic oxetanocin G (C.OXT-G) has potent anti-herpes simplex virus activity and high water solubility, so the clinical effect of C.OXT-G eyedrops on ulcerative herpetic keratitis was evaluated. Studies were conducted on the corneal ulcers in 37 eyes of 27 patients. Patients with typical dendritic or geographic corneal ulcers were treated with 0.1% C.OXT-G eyedrops, applied five times a day, together with eyedrops of an antibiotic applied four times a day. The eyes were examined at least twice a week until the ulcers healed, and thereafter at intervals for up to 3 months. All of the ulcers healed, their average healing time being 4.9 (SD 2.2) (range 2 to 9) days. The ulcers in 20 of the 37 eyes were induced by the use of corticosteroid or immunosuppressive drugs, and their average healing time was 4.8 (2.3) days. No adverse drug reactions were seen during the observation period in this trial. Eyedrops containing 0.1% C.OXT-G are excellent and safe for treatment of herpes simplex corneal ulcers in humans. (日)
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| ○キーワード (推奨): | 1. | (英) Administration, Topical (日) (読)
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| 2. | (英) Anti-Infective Agents (日) (読)
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| 3. | (英) Antiviral Agents (日) (読)
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| 4. | (英) Corneal Ulcer (日) (読)
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| 5. | (英) Eye Infections, Viral (日) (読)
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| 6. | (英) Female (日) (読)
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| 7. | (英) Guanine (日) (読)
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| 8. | (英) Humans (日) (読)
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| 9. | (英) Keratitis, Herpetic (日) (読)
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| 10. | (英) Male (日) (読)
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| 11. | (英) Middle Aged (日) (読)
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| 12. | (英) Ofloxacin (日) (読)
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| 13. | (英) Ophthalmic Solutions (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The British journal of Ophthalmology (British Medical Association)
(pISSN: 0007-1161, eISSN: 1468-2079)
| ○ISSN (任意): | □ | 0007-1161
ISSN: 0007-1161
(pISSN: 0007-1161, eISSN: 1468-2079) Title: The British journal of ophthalmologyTitle(ISO): Br J OphthalmolPublisher: BMJ Group (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 80
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| ○号 (必須): | □ | 5
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| ○頁 (必須): | □ | 413 415
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1996年 5月 初日 (平成 8年 5月 初日)
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| ○URL (任意): |
| ○DOI (任意): |
| ○PMID (任意): | □ | 8695561 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS : | □ | A1996UM86400010
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| ○Scopus (任意): | 1. | 2-s2.0-0029996853
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| ○researchmap (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Clinical Trial (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) OtherID: PMC505491 (日)
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