『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=132326EID:132326, Map:0, LastModified:2013年6月16日(日) 19:56:09, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[近藤 和也], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Sogawa Ken-ichi (日) (読)
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2.近藤 和也 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.看護学系.臨床腫瘍医療学]/[徳島大学.医学部.保健学科.看護学専攻.成人·高齢者看護学講座])
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3. (英) Fujino Haruhiko (日) (読)
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4. (英) Takahashi Yuji (日) (読)
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5.三好 孝典
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6.先山 正二
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7. (英) Mukai Kiyoshi (日) (読)
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8. (英) Monden Yasumasa (日) (読)
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題名 (必須): (英) Increased expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 is correlated with poor prognostic variables in patients with thymic epithelial tumors  (日)    [継承]
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要約 (任意): (英) A distinction between noninvasive, invasive, and metastatic thymoma on the basis of the cytologic features is difficult. The current study investigated whether the expression of MMP and TIMP was correlated with tumor invasiveness and prognosis in patients with thymoma. Tumor tissue samples were obtained from 42 patients with thymic epithelial tumors between 1974 and 2001 at Tokushima University Hospital. Three-micrometer-thick, formalin-fixed, paraffin-embedded tissue sections were immunostained using specific antibodies against MMP-2, MMP-9, TIMP-1, and TIMP-2. MMP-2 expression was detected in 30 tumors (71%), and TIMP-2 expression was detected in 31 tumors (74%). MMP-9 expression was detected in 22 of 36 tumors (61%), and TIMP-1 expression was detected in only 7 tumors (19%). MMP-2 and TIMP-2 expression levels were very low (10% and 0%, respectively) in noninvasive tumors but were very high (91% and 97%, respectively) in invasive tumors. In thymic epithelial tumors, the more progressive the clinical stage of tumor, the higher the strongly positive rate of MMP-2 and TIMP-2 expression. There was no correlation between positivity for MMP-9 and stage. Twenty-five percent of Type AB thymomas and 50% of Type B1 thymomas expressed MMP-2 and TIMP-2. Most of Type A, Type B2, Type B3, and Type C thymomas expressed MMP-2 and TIMP-2. There were significant differences in disease-free survival at 5 years between patients without and with MMP-2 expression (91% vs. 55%, respectively) and patients without and with TIMP-2 expression (100% vs. 53%, respectively). MMP-2 and TIMP-2 are key enzymes for invasiveness of thymic epithelial tumors. The expression of these proteins can predict a poor outcome in patients with thymoma.  (日)    [継承]
キーワード (推奨): 1. (英) thymoma (日) (読) [継承]
2. (英) matrix metalloproteinase (日) (読) [継承]
3. (英) tissue inhibitor of metalloproteinase (日) (読) [継承]
4. (英) invasiveness (日) (読) [継承]
5.免疫組織化学 (immunohistochemistry) [継承]
発行所 (推奨): (英) American Cancer Society (日) (読) [継承]
誌名 (必須): Cancer (American Cancer Society)
(pISSN: 0008-543X, eISSN: 1097-0142)

ISSN (任意): 0008-543X
ISSN: 0008-543X (pISSN: 0008-543X, eISSN: 1097-0142)
Title: Cancer
Title(ISO): Cancer
Supplier: American Cancer Society
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 98 [継承]
(必須): 9 [継承]
(必須): 1811 1821 [継承]
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年月日 (必須): 西暦 2003年 9月 26日 (平成 15年 9月 26日) [継承]
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DOI (任意): 10.1002/cncr.11725    (→Scopusで検索) [継承]
PMID (任意): 14584061    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Oncological and Regenerative Surgery, School of Medicine, University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Ken-ichi Sogawa, Kazuya Kondo, Haruhiko Fujino, Yuji Takahashi, Takanori Miyoshi, Shoji Sakiyama, Kiyoshi Mukai and Yasumasa Monden : Increased expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 is correlated with poor prognostic variables in patients with thymic epithelial tumors, Cancer, Vol.98, No.9, 1811-1821, 2003.
欧文冊子 ● Ken-ichi Sogawa, Kazuya Kondo, Haruhiko Fujino, Yuji Takahashi, Takanori Miyoshi, Shoji Sakiyama, Kiyoshi Mukai and Yasumasa Monden : Increased expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 is correlated with poor prognostic variables in patients with thymic epithelial tumors, Cancer, Vol.98, No.9, 1811-1821, 2003.

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