『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Ago Tetsuro (日) (読)
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2. (英) Kitazono Takanari (日) (読)
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3. (英) Kuroda Junya (日) (読)
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4. (英) Kumai Yasuhiro (日) (読)
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5. (英) Kamouchi Masahiro (日) (読)
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6. (英) Ooboshi Hiroaki (日) (読)
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7. (英) Wakisaka Masanori (日) (読)
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8. (英) Kawahara Tsukasa (日) (読)
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9.六反 一仁
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10. (英) Ibayashi Setsuro (日) (読)
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11. (英) Iida Mitsuo (日) (読)
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題名 (必須): (英) NAD(P)H Oxidases in Rat Basilar Arterial Endothelial Cells  (日)    [継承]
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要約 (任意): (英) Reactive oxygen species (ROS) may play a critical role in the regulation of vascular tone and development of vascular diseases, such as stroke. NAD(P)H oxidase is a major source of ROS in vascular cells, including endothelial cells. It has been considered that Nox2 and Nox4 are exclusively expressed among Nox homologues in the endothelial cells of noncerebral blood vessels. However, the precise molecular identity of the NAD(P)H oxidase in the endothelial cells of the cerebral arteries is not fully understood. We examined the expression of Nox homologues and their activation mechanism in the endothelial cells of the cerebral arteries. We isolated and cultured basilar artery endothelial cells (BAECs) of Sprague-Dawley rats. Expression of NAD(P)H oxidase was examined by reverse-transcription-polymerase chain reaction (RT-PCR) and immunohistological staining. RT-PCR disclosed abundant expression of Nox4 with marginal Nox2 in BAEC. In addition, Nox1 was expressed highly both at mRNA and protein levels in BAECs. Immunohistological staining also showed the prominent expression of Nox1 in the endothelial cells of the basilar artery. With respect to the cytosolic components of NAD(P)H oxidases, BAECs expressed p67phox and, to a lesser extent, p47phox, Noxo1, and Noxa1. Both NADH and NADPH induced superoxide production of the BAEC membranes. The phagocyte-type cytosolic components, p47phox and p67phox, significantly enhanced the NADH-induced superoxide production of the BAEC membranes, whereas the components failed to increase the NADPH-induced superoxide production. Nox1 is highly expressed in the endothelial cells of the cerebral arteries along with Nox2 and Nox4, and the endothelial NAD(P)H oxidase of the cerebral arteries may have a unique activation mechanism by the phagocyte-type cytosolic components.  (日)    [継承]
キーワード (推奨): 1. (英) cerebrovascular disorders (日) (読) [継承]
2. (英) endothelium (日) (読) [継承]
3. (英) free radicals (日) (読) [継承]
4. (英) NAD(P)H oxidase (日) (読) [継承]
発行所 (推奨): American Heart Association [継承]
誌名 (必須): Stroke ([American Heart Association])
(pISSN: 0039-2499, eISSN: 1524-4628)

ISSN (任意): 1524-4628
ISSN: 0039-2499 (pISSN: 0039-2499, eISSN: 1524-4628)
Title: Stroke
Title(ISO): Stroke
Publisher: American Heart Association
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 36 [継承]
(必須): 5 [継承]
(必須): 1040 1046 [継承]
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年月日 (必須): 西暦 2005年 5月 初日 (平成 17年 5月 初日) [継承]
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DOI (任意): 10.1161/01.STR.0000163111.05825.0b    (→Scopusで検索) [継承]
PMID (任意): 15845888    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. agou@intmed2.med.kyushu-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tetsuro Ago, Takanari Kitazono, Junya Kuroda, Yasuhiro Kumai, Masahiro Kamouchi, Hiroaki Ooboshi, Masanori Wakisaka, Tsukasa Kawahara, Kazuhito Rokutan, Setsuro Ibayashi and Mitsuo Iida : NAD(P)H Oxidases in Rat Basilar Arterial Endothelial Cells, Stroke, Vol.36, No.5, 1040-1046, 2005.
欧文冊子 ● Tetsuro Ago, Takanari Kitazono, Junya Kuroda, Yasuhiro Kumai, Masahiro Kamouchi, Hiroaki Ooboshi, Masanori Wakisaka, Tsukasa Kawahara, Kazuhito Rokutan, Setsuro Ibayashi and Mitsuo Iida : NAD(P)H Oxidases in Rat Basilar Arterial Endothelial Cells, Stroke, Vol.36, No.5, 1040-1046, 2005.

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