『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=131055)

EID=131055EID:131055, Map:0, LastModified:2018年12月3日(月) 14:27:12, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[[副研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Harashima H (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Komatsu S (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Kojima H (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Yanagi C (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Morioka Y (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Naito M (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.際田 弘志
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Species difference in the disposition of liposomes among mice, rats, and rabbits: Allometric relationship and species dependent hepatic uptake mechanism  (日)    [継承]
副題 (任意):
要約 (任意): (英) The species difference in the pharmacokinetics of liposomes was investigated in mice, rats and rabbits. Liposomes were intravenously injected at doses of 1, 10 and 100 (nmol/g body weight), and the time courses of liposomes in blood, liver and spleen were measured. Pharmacokinetic parameters were regressed as a function of body weight (BW) and dose of liposomes (D). The uptake mechanism of liposomes was also examined with the isolated perfused liver between rats and mice. Mean residence time increased with the increase of BW and D of liposomes. This increase of mean residence time resulted from the decreased total body clearance, which was principally explained by the species difference in the hepatic uptake clearance (CLh) of liposomes. The parameter CLh was regressed well by a multiple regression as a function of BW and D. In this analysis, an exponent for BW was around 0.5, which clearly indicates that smaller animals have higher uptake clearance per unit BW. Immunohistochemical analysis revealed that there was no significant difference in the density of Kupffer cells among these species. This suggest that the species difference in CLh resulted not from the density of Kupffer cells but from the uptake ability of Kupffer cells among species. In the isolated perfused liver, the hepatic uptake of liposomes was mainly explained by opsonin dependent uptake in rats, while opsonin independent uptake in mice. These quantitative and qualitative information on the species difference of liposome disposition will provide an useful information for constructing a drug delivery system using liposomes.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Body Weight (日) (読) [継承]
3. (英) Dose-Response Relationship, Drug (日) (読) [継承]
4.免疫組織化学 (immunohistochemistry) [継承]
5. (英) In Vitro Techniques (日) (読) [継承]
6. (英) Kupffer Cells (日) (読) [継承]
7.リポソーム (liposomes) [継承]
8. (英) Liver (日) (読) [継承]
9. (英) Mice (日) (読) [継承]
10. (英) Opsonin Proteins (日) (読) [継承]
11. (英) Rabbits (日) (読) [継承]
12. (英) Rats (日) (読) [継承]
13. (英) Rats, Wistar (日) (読) [継承]
14. (英) Species Specificity (日) (読) [継承]
15. (英) Spleen (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Pharmaceutical Research (American Association of Pharmaceutical Scientists)
(pISSN: 0724-8741, eISSN: 1573-904X)

ISSN (任意): 0724-8741
ISSN: 0724-8741 (pISSN: 0724-8741, eISSN: 1573-904X)
Title: Pharmaceutical research
Title(ISO): Pharm Res
Supplier: Kluwer Online
Publisher: Springer
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 13 [継承]
(必須): 7 [継承]
(必須): 1049 1054 [継承]
都市 (任意):
年月日 (必須): 西暦 1996年 7月 初日 (平成 8年 7月 初日) [継承]
URL (任意):
DOI (任意): 10.1023/A:1016058724452    (→Scopusで検索) [継承]
PMID (任意): 8842043    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意): 2-s2.0-0029739890 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● H Harashima, S Komatsu, H Kojima, C Yanagi, Y Morioka, M Naito and Hiroshi Kiwada : Species difference in the disposition of liposomes among mice, rats, and rabbits: Allometric relationship and species dependent hepatic uptake mechanism, Pharmaceutical Research, Vol.13, No.7, 1049-1054, 1996.
欧文冊子 ● H Harashima, S Komatsu, H Kojima, C Yanagi, Y Morioka, M Naito and Hiroshi Kiwada : Species difference in the disposition of liposomes among mice, rats, and rabbits: Allometric relationship and species dependent hepatic uptake mechanism, Pharmaceutical Research, Vol.13, No.7, 1049-1054, 1996.

関連情報

Number of session users = 0, LA = 0.19, Max(EID) = 383418, Max(EOID) = 1024827.