『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=130907)

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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Yoshida Tomonori (日) (読)
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2.東 博之
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3.粟飯原 賢一 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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4. (英) Fujimura Mitsunori (日) (読)
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5.赤池 雅史 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.医療教育学])
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6.三ツ井 貴夫
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7.松本 俊夫
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題名 (必須): (英) Vascular smooth muscle cell proliferation is dependent upon upregulation of mitochondrial transcription factor A (mtTFA) expression in injured rat carotid artery  (日)    [継承]
副題 (任意):
要約 (任意): (英) Consistent with the physiological response to increased energy demand in proliferating cells, the number of mitochondria is upregulated in synthetic states of vascular smooth muscle cells (VSMC) in atherosclerotic lesion. We hypothesized that mitochondrial transcription factor A (mtTFA), a prerequisite factor for the transcription and replication of mtDNA, may be upregulated in VSMC of injured rat carotid artery, and that inhibition of its expression can attenuate the intimal thickening. Changes of intimal thickening and mtTFA expression by a treatment with antisense oligodeoxynucleotides (ODN) for mtTFA were investigated in balloon-injured rat carotid artery model. The expression of mtTFA was upregulated as early as 3 h up to 7 days after balloon injury. Delivery of ansisense ODN for mtTFA from adventitia side to injured arterial wall caused a significant decrease in intima-to-media (I/M) ratio. Furthermore, the increase in immunoreactivity and mRNA expression of mtTFA in injured artery as well as the number of mitochondria in intimal VSMC was abrogated by antisense ODN treatment. These data demonstrate that expression of mtTFA is upregulated in intimal VSMC of injured rat carotid artery, and that suppression of mtTFA expression by antisense ODN can attenuate intimal thickening after balloon injury.  (日)    [継承]
キーワード (推奨): 1. (英) Antisense oligodeoxynucleotide (日) (読) [継承]
2. (英) Arterial injury (日) (読) [継承]
3. (英) Intimal thickening (日) (読) [継承]
4. (英) Dedifferentiation (日) (読) [継承]
5. (英) Restenosis (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Atherosclerosis (European Atherosclerosis Society)
(pISSN: 0021-9150, eISSN: 1879-1484)

ISSN (任意): 0021-9150
ISSN: 0021-9150 (pISSN: 0021-9150, eISSN: 1879-1484)
Title: Atherosclerosis
Title(ISO): Atherosclerosis
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 178 [継承]
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(必須): 39 47 [継承]
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年月日 (必須): 西暦 2005年 1月 初日 (平成 17年 1月 初日) [継承]
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DOI (任意): 10.1016/j.atherosclerosis.2004.08.029    (→Scopusで検索) [継承]
PMID (任意): 15585199    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tomonori Yoshida, Hiroyuki Azuma, Ken-ichi Aihara, Mitsunori Fujimura, Masashi Akaike, Takao Mitsui and Toshio Matsumoto : Vascular smooth muscle cell proliferation is dependent upon upregulation of mitochondrial transcription factor A (mtTFA) expression in injured rat carotid artery, Atherosclerosis, Vol.178, No.1, 39-47, 2005.
欧文冊子 ● Tomonori Yoshida, Hiroyuki Azuma, Ken-ichi Aihara, Mitsunori Fujimura, Masashi Akaike, Takao Mitsui and Toshio Matsumoto : Vascular smooth muscle cell proliferation is dependent upon upregulation of mitochondrial transcription factor A (mtTFA) expression in injured rat carotid artery, Atherosclerosis, Vol.178, No.1, 39-47, 2005.

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