『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Takamori Nobuyuki (日) (読)
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2.東 博之
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3. (英) Kato Midori (日) (読)
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4. (英) Hashizume Shunji (日) (読)
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5.粟飯原 賢一 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).糖尿病・代謝疾患治療医学])
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6.赤池 雅史 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.医療教育学])
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7. (英) Tamura Katsuya (日) (読)
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8.松本 俊夫
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題名 (必須): (英) High plasma heparin cofactor II activity is associated with reduced incidence of in-stent restenosis after percutaneous coronary intervention  (日)    [継承]
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要約 (任意): (英) Thrombin plays an important role in the development of atherosclerosis and restenosis after percutaneous coronary intervention. Because heparin cofactor II (HCII) inhibits thrombin action in the presence of dermatan sulfate, which is abundantly present in arterial wall, HCII may affect vascular remodeling by modulating thrombin action. We hypothesized that patients with high plasma HCII activity may show a reduced incidence of in-stent restenosis (ISR). Sequential coronary arteries (n=166) with NIR stent (Boston Scientific Corp) implantation in 134 patients were evaluated before, immediately after, and at 6 months after percutaneous coronary intervention. Patients were divided into the following groups: high HCII (> or =110%, 45 lesions in 36 patients), normal HCII (> or =80% and <110%, 81 lesions in 66 patients), and low HCII (<80%, 40 lesions in 32 patients). Percent diameter stenosis at follow-up in the high-HCII group (18.7%) was significantly lower (P=0.046) than that in the normal-HCII group (30.3%) or the low-HCII group (29.0%). The ISR rate in the high-HCII group (6.7%) was significantly lower than that in the low-HCII group (30.0%) (P=0.0039). Furthermore, multivariate analysis demonstrated that high plasma HCII activity is an independent factor in reducing the incidence of angiographic restenosis (odds ratio, 0.953/1% increase of HCII; 95% CI, 0.911 to 0.998). The results demonstrate that HCII may have a hitherto unrecognized effect in inhibiting ISR. The effect of HCII may be mediated by inactivating thrombin in injured arteries, thereby inhibiting vascular smooth muscle cell migration and proliferation.  (日)    [継承]
キーワード (推奨): 1. (英) cardiovascular diseases (日) (読) [継承]
2. (英) angioplasty (日) (読) [継承]
3. (英) atherosclerosis (日) (読) [継承]
4. (英) thrombin (日) (読) [継承]
5. (英) dermatan sulfate (日) (読) [継承]
発行所 (推奨): American Heart Association [継承]
誌名 (必須): Circulation ([American Heart Association])
(pISSN: 0009-7322, eISSN: 1524-4539)

ISSN (任意): 1524-4539
ISSN: 0009-7322 (pISSN: 0009-7322, eISSN: 1524-4539)
Title: Circulation
Title(ISO): Circulation
Publisher: American Heart Association
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 481 486 [継承]
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年月日 (必須): 西暦 2004年 1月 26日 (平成 16年 1月 26日) [継承]
URL (任意): http://circ.ahajournals.org/cgi/content/abstract/109/4/481 [継承]
DOI (任意): 10.1161/01.CIR.0000109695.39671.37    (→Scopusで検索) [継承]
PMID (任意): 14744972    (→Scopusで検索) [継承]
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WOS (任意): 000188669400008 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medicine, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Clinical Trial  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Nobuyuki Takamori, Hiroyuki Azuma, Midori Kato, Shunji Hashizume, Ken-ichi Aihara, Masashi Akaike, Katsuya Tamura and Toshio Matsumoto : High plasma heparin cofactor II activity is associated with reduced incidence of in-stent restenosis after percutaneous coronary intervention, Circulation, Vol.109, No.4, 481-486, 2004.
欧文冊子 ● Nobuyuki Takamori, Hiroyuki Azuma, Midori Kato, Shunji Hashizume, Ken-ichi Aihara, Masashi Akaike, Katsuya Tamura and Toshio Matsumoto : High plasma heparin cofactor II activity is associated with reduced incidence of in-stent restenosis after percutaneous coronary intervention, Circulation, Vol.109, No.4, 481-486, 2004.

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