| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | 香美 祥二 ([徳島大学])
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| 2. | 近藤 秀治
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| 3. | (英) Klemens Loster (日) (読)
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| 4. | (英) Reutter Werner (日) (読)
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| 5. | 漆原 真樹 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.内科系.小児科学]/[徳島大学.病院.診療科.小児·周産·女性科.小児科])
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| 6. | 北村 明子
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| 7. | (英) Kobayashi Shoko (日) (読)
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| 8. | 黒田 𣳾弘
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| ○題名 (必須): | □ | (英) Collagen Type I Modulates the Platelet-Derived Growth Factor (PDGF) Regulation of the Growth and Expression of β1 Integrins by Rat Mesangial Cells (日)
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| ○要約 (任意): | □ | (英) Mesangial cell (MC) proliferation and the deposition of collagen type I (collagen I) are the major pathological features in many types of glomerulonephritis (GN). Recent work suggested that beta-integrins play a critical role in the cell proliferation and extracellular matrix (ECM) remodeling observed in tissue repair after injury. To examine the involvement of beta-integrins in MC proliferation in association with the interaction of MCs with pathological collagen I, we investigated the effect of a prominent mitogen, platelet-derived growth factor-BB (PDGF-BB) on the growth and expression of beta-integrins by MCs cultured on plastic or in a three-dimensional collagen I gel. Immunoprecipitation using 35S-metabolic labeling, flow cytometry and a 3H-thymidine-uptake analysis demonstrated that PDGF-BB stimulated the cell mitogenicity and the expression of alpha5beta1 integrin (a fibronectin receptor), but not alpha1beta1 integrin (a collagen and laminin receptor) of MCs on plastic, in a dose-dependent manner. In contrast, MCs in the collagen I gels showed no significant changes in mitogenicity or alpha1beta1 and alpha5beta1 integrin expression, but increased alpha1beta1 integrin-mediated gel contraction was observed after PDGF-BB stimulation. Thus, the parallel up-regulation of MC-mitogenicity and alpha5beta1 integrin expression by PDGF-BB suggested that alpha5beta1 integrin is an important ECM receptor involved in the proliferative phenotype of MC. A spatial interaction between MCs and pathological collagen I in GN may influence the PDGF regulation of the MC phenotype regarding the cell growth and the expression of beta1 integrins. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antigens, CD29 (日) (読)
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| 3. | 細胞分裂 (cell division)
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| 4. | (英) Cells, Cultured (日) (読)
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| 5. | コラーゲン (collagen)
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| 6. | (英) Glomerular Mesangium (日) (読)
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| 7. | (英) Platelet-Derived Growth Factor (日) (読)
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| 8. | (英) Proto-Oncogene Proteins c-sis (日) (読)
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| 9. | (英) Rats (日) (読)
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| 10. | (英) Rats, Sprague-Dawley (日) (読)
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| ○発行所 (推奨): | □ | Academic Press (->組織[Elsevier Science])
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| ○誌名 (必須): | □ | Biochemical and Biophysical Research Communications ([Elsevier])
(pISSN: 0006-291X, eISSN: 1090-2104)
| ○ISSN (任意): | □ | 0006-291X
ISSN: 0006-291X
(pISSN: 0006-291X, eISSN: 1090-2104) Title: Biochemical and biophysical research communicationsTitle(ISO): Biochem Biophys Res CommunPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 252
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 728 732
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| ○年月日 (必須): | □ | 西暦 1998年 11月 27日 (平成 10年 11月 27日)
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| ○URL (任意): | □ | http://dx.doi.org/10.1006/bbrc.1998.9733
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| ○DOI (任意): | □ | 10.1006/bbrc.1998.9733 (→Scopusで検索)
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| ○PMID (任意): | □ | 9837774 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000077339700034
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| ○備考 (任意): | 1. | (英) Article.Affiliation: School of Medicine, University of Tokushima, Tokushima, 770-0042, Japan. kagami@medclin.clin.med.tokushima-u.ac.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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