| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Kondo Shuji (日) (読)
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| 2. | 香美 祥二 ([徳島大学])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 3. | 木戸 博 ([徳島大学.先端酵素学研究所.重点研究部門])
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| 4. | (英) Frank Strutz (日) (読)
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| 5. | (英) Gerhard A. Muller (日) (読)
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| 6. | 黒田 𣳾弘
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| ○題名 (必須): | □ | (英) Role of Mast Cell Tryptase in Renal Interstitial Fibrosis (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Renal interstitial fibrosis is characterized by increased proliferation of fibroblasts and excessive accumulation of extracellular matrix. Mast cell tryptase has been implicated in the development of tissue fibrosis in skin and lungs. However, the significance of mast cell tryptase in human renal diseases has not been investigated. The potential role of mast cell-derived tryptase in the development of renal fibrosis was studied using immunohistochemical techniques and cultured human renal fibroblast cell lines. Semiquantitative immunostaining analysis of samples from 70 patients with several renal diseases, including IgA glomerulonephritis (GN) (n = 30), non-IgA GN (n = 5), membranous GN (n = 5), focal segmental glomerulosclerosis (n = 4), minor glomerular abnormalities (n = 5), lupus nephritis (n = 3), and acute or chronic tubulointerstitial nephritis (n = 18), revealed that the degree of renal interstitial fibrosis was well correlated with the number of infiltrating tryptase-positive mast cells (P < 0.01). Mast cells could not be detected in damaged glomeruli in any form of renal disease. [(3)H]Thymidine uptake experiments demonstrated that DNA synthesis by cultured renal fibroblasts was increased with the concentration of tryptase (0.5 to 5 nM) coincubated with heparin and was suppressed by coincubation with the protease inhibitors leupeptin and benzamidine hydrochloride. Tryptase alone also increased DNA synthesis by fibroblasts but exhibited less effectiveness, compared with the combination of tryptase and heparin. Conversely, heparin alone suppressed DNA synthesis by fibroblasts. Metabolic [(35)S]methionine-labeling experiments with cultured renal fibroblasts indicated that tryptase increased the synthesis of fibronectin and collagen type I, in a dose-dependent manner. These findings suggest that mast cell tryptase plays a role in the proliferation and extracellular matrix protein production of renal interstitial fibroblasts and thus contributes to the development of renal interstitial fibrosis. (日)
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| ○キーワード (推奨): | 1. | 細胞分裂 (cell division)
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| 2. | (英) Cells, Cultured (日) (読)
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| 3. | コラーゲン (collagen)
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| 4. | (英) Extracellular Matrix Proteins (日) (読)
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| 5. | (英) Fibroblasts (日) (読)
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| 6. | (英) Fibrosis (日) (読)
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| 7. | (英) Humans (日) (読)
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| 8. | (英) Kidney (日) (読)
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| 9. | (英) Kidney Diseases (日) (読)
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| 10. | (英) Mast Cells (日) (読)
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| 11. | (英) Mitogens (日) (読)
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| 12. | (英) RNA, Messenger (日) (読)
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| 13. | (英) Serine Endopeptidases (日) (読)
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| 14. | (英) Tryptases (日) (読)
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| ○発行所 (推奨): | □ | (英) American Society of Nephrology (日) (読)
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| ○誌名 (必須): | □ | Journal of the American Society of Nephrology (American Society of Nephrology)
(pISSN: 1046-6673, eISSN: 1533-3450)
| ○ISSN (任意): | □ | 1046-6673
ISSN: 1046-6673
(pISSN: 1046-6673, eISSN: 1533-3450) Title: Journal of the American Society of Nephrology : JASNTitle(ISO): J Am Soc NephrolPublisher: American Society of Nephrology (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 12
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| ○号 (必須): | □ | 8
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| ○頁 (必須): | □ | 1668 1676
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2001年 8月 初日 (平成 13年 8月 初日)
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| ○URL (任意): |
| ○DOI (任意): |
| ○PMID (任意): | □ | 11461939 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-0034924896
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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