『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.三ツ井 貴夫
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2.東 博之
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3. (英) Nagasawa Masakazu (日) (読)
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4. (英) Iuchi Takahiko (日) (読)
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5.赤池 雅史 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.医療教育学])
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6. (英) Odomi Masaaki (日) (読)
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7.松本 俊夫
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題名 (必須): (英) Chronic corticosteroid administration causes mitochondrial dysfunction in skeletal muscle  (日)    [継承]
副題 (任意):
要約 (任意): (英) Corticosteroid myopathy is a major clinical problem in patients undergoing chronic corticosteroid treatment and shows insidious and progressive muscle atrophy in proximal limbs. Although several mechanisms underlying the pathophysiology of muscle injury have been postulated, precise pathogenesis is still not clear. We evaluated the mitochondrial functions in patients receiving corticosteroids compared with those in healthy controls or patients not receiving corticosteroids. The serum levels and total production of lactate were investigated by an aerobic exercise test using a bicycle ergometer. Mitochondrial respiratory activities and oxidative damage in biopsied skeletal muscles were also studied. The results of aerobic exercise tests revealed a significant overproduction of lactate in patients treated with corticosteroids ( p < 0.005), which was positively correlated with total corticosteroid doses administered ( p < 0.0001). In these patients, mitochondrial enzyme activity in complex I was significantly decreased ( p < 0.05) and oxidative damage of biopsied skeletal muscle was remarkable both in mitochondrial and nuclear DNAs ( p < 0.001). The results suggest that chronic corticosteroid administration induces mitochondrial dysfunction and oxidative damage in skeletal muscles, which may be the pathogenesis, at least in part, of corticosteroid-induced myopathy.  (日)    [継承]
キーワード (推奨): 1. (英) Corticosteroid myopathy (日) (読) [継承]
2. (英) Mitochondrial respiratory activity (日) (読) [継承]
3. (英) oxidative damage (日) (読) [継承]
4. (英) aerobic exercise (日) (読) [継承]
5. (英) biopsied skeletal muscle (日) (読) [継承]
発行所 (推奨): Springer-Verlag [継承]
誌名 (必須): Journal of Neurology (European Neurological Society)
(pISSN: 0340-5354, eISSN: 1432-1459)

ISSN (任意): 0340-5354
ISSN: 0340-5354 (pISSN: 0340-5354, eISSN: 1432-1459)
Title: Journal of neurology
Title(ISO): J Neurol
Supplier: Springer Online Journal Archive
Publisher: Springer Berlin Heidelberg
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 249 [継承]
(必須): 8 [継承]
(必須): 1004 1009 [継承]
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年月日 (必須): 西暦 2002年 8月 初日 (平成 14年 8月 初日) [継承]
URL (任意): http://www.springerlink.com/(0j535v453bucaeysfnpuh1zq)/app/home/contribution.asp?referrer=parent&backto=issue,9,40;journal,58,145;linkingpublicationresults,1:100440,1 [継承]
DOI (任意): 10.1007/s00415-002-0774-5    (→Scopusで検索) [継承]
PMID (任意): 12195445    (→Scopusで検索) [継承]
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WOS (任意): 000177632400009 [継承]
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備考 (任意): 1.(英) Article.Affiliation: First Department of Internal Medicine, School of Medicine, The University of Tokushima, Kuramoto-3-18-15, Tokushima 770-8503, Japan. tmitsui@clin.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Takao Mitsui, Hiroyuki Azuma, Masakazu Nagasawa, Takahiko Iuchi, Masashi Akaike, Masaaki Odomi and Toshio Matsumoto : Chronic corticosteroid administration causes mitochondrial dysfunction in skeletal muscle, Journal of Neurology, Vol.249, No.8, 1004-1009, 2002.
欧文冊子 ● Takao Mitsui, Hiroyuki Azuma, Masakazu Nagasawa, Takahiko Iuchi, Masashi Akaike, Masaaki Odomi and Toshio Matsumoto : Chronic corticosteroid administration causes mitochondrial dysfunction in skeletal muscle, Journal of Neurology, Vol.249, No.8, 1004-1009, 2002.

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