『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=130807EID:130807, Map:0, LastModified:2014年2月24日(月) 14:46:30, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.工学部.生物工学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.Johns Hopkins University School of Medicine [継承]
著者 (必須): 1. (英) Krishnamachary Balaji (日) (読)
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学籍番号 (推奨):
[継承]
2. (英) Zagzag David (日) (読)
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学籍番号 (推奨):
[継承]
3.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Rainey Karin (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5. (英) Okuyama Hiroaki (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Baek H. Jin (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
[継承]
7. (英) Semenza L. Gregg (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) HIF-1-dependent Repression of E-cadherin in VHL-null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B  (日)    [継承]
副題 (任意):
要約 (任意): (英) A critical event in the pathogenesis of invasive and metastatic cancer is E-cadherin loss of function. Renal clear cell carcinoma (RCC) is characterized by loss of function of the von Hippel-Lindau tumor suppressor (VHL), which negatively regulates hypoxia-inducible factor-1 (HIF-1). Loss of E-cadherin expression and decreased cell-cell adhesion in VHL-null RCC4 cells were corrected by enforced expression of VHL, a dominant-negative HIF-1alpha mutant, or a short hairpin RNA directed against HIF-1alpha. In human RCC biopsies, expression of E-cadherin and HIF-1alpha was mutually exclusive. The expression of mRNAs encoding TCF3, ZFHX1A, and ZFHX1B, which repress E-cadherin gene transcription, was increased in VHL-null RCC4 cells in a HIF-1-dependent manner. Thus, HIF-1 contributes to the epithelial-mesenchymal transition in VHL-null RCC by indirect repression of E-cadherin.  (日)    [継承]
キーワード (推奨): 1. (英) Basic Helix-Loop-Helix Transcription Factors (日) (読) [継承]
2. (英) Biopsy (日) (読) [継承]
3. (英) Cadherins (日) (読) [継承]
4. (英) Carcinoma, Renal Cell (日) (読) [継承]
5. (英) Cell Adhesion (日) (読) [継承]
6. (英) Down-Regulation (日) (読) [継承]
7. (英) Epithelial Cells (日) (読) [継承]
8. (英) Gene Expression Regulation, Neoplastic (日) (読) [継承]
9. (英) Homeodomain Proteins (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Hypoxia-Inducible Factor 1 (日) (読) [継承]
12.免疫組織化学 (immunohistochemistry) [継承]
13. (英) Kidney Neoplasms (日) (読) [継承]
14. (英) Mesoderm (日) (読) [継承]
15. (英) RNA, Messenger (日) (読) [継承]
16. (英) RNA, Small Interfering (日) (読) [継承]
17. (英) Repressor Proteins (日) (読) [継承]
18. (英) Transcription Factors (日) (読) [継承]
19. (英) Transcription, Genetic (日) (読) [継承]
20. (英) Von Hippel-Lindau Tumor Suppressor Protein (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Cancer Research (American Assotiation for Cancer Research)
(pISSN: 0008-5472, eISSN: 1538-7445)

ISSN (任意): 0008-5472
ISSN: 0008-5472 (pISSN: 0008-5472, eISSN: 1538-7445)
Title: Cancer research
Title(ISO): Cancer Res
Publisher: American Association for Cancer Research
 (NLM Catalog  (Scopus  (Scopus  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
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(必須): 66 [継承]
(必須): 5 [継承]
(必須): 2725 2731 [継承]
都市 (任意):
年月日 (必須): 西暦 2006年 1月 初日 (平成 18年 1月 初日) [継承]
URL (任意):
DOI (任意): 10.1158/0008-5472.CAN-05-3719    (→Scopusで検索) [継承]
PMID (任意): 16510593    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000235826400032 [継承]
Scopus (任意): 2-s2.0-33645090169 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, N.I.H., Extramural  (日)    [継承]

標準的な表示

和文冊子 ● Balaji Krishnamachary, David Zagzag, Hideko Nagasawa, Karin Rainey, Hiroaki Okuyama, Jin H. Baek and Gregg L. Semenza : HIF-1-dependent Repression of E-cadherin in VHL-null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B, Cancer Research, Vol.66, No.5, 2725-2731, 2006.
欧文冊子 ● Balaji Krishnamachary, David Zagzag, Hideko Nagasawa, Karin Rainey, Hiroaki Okuyama, Jin H. Baek and Gregg L. Semenza : HIF-1-dependent Repression of E-cadherin in VHL-null Renal Cell Carcinoma Mediated by TCF3, ZFHX1A, and ZFHX1B, Cancer Research, Vol.66, No.5, 2725-2731, 2006.

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