『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=130746)

EID=130746EID:130746, Map:0, LastModified:2018年3月20日(火) 16:40:25, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[赤池 雅史], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.三ツ井 貴夫
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[継承]
2. (英) Umaki Yoshifumi (日) (読)
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[継承]
3. (英) Nagasawa Masakazu (日) (読)
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[継承]
4.赤池 雅史 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.社会医学系.医療教育学])
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学籍番号 (推奨):
[継承]
5. (英) Aki Kenji (日) (読)
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[継承]
6.東 博之
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学籍番号 (推奨):
[継承]
7.尾崎 修治
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[継承]
8. (英) Odomi Masaaki (日) (読)
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9.松本 俊夫
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題名 (必須): (英) Mitochondrial damage in patients with long-term corticosteroid therapy: development of oculoskeletal symptoms similar to mitochondrial disease  (日)    [継承]
副題 (任意):
要約 (任意): (英) Two patients with long-term corticosteroid administration sporadically developed limb muscle wasting followed by ophthalmoplegia, and the skeletal muscle pathology revealed ragged-red fibers (RRFs) with abnormal mitochondria, in addition to the findings of corticosteroid myopathy. The oculoskeletal symptoms of the present cases resemble those of chronic progressive external ophthalmoplegia, a type of mitochondrial disease. The ocular muscles have more RRFs than limb muscles, and large multiple deletions of mitochondrial DNA was detected in ocular and limb muscles of the two patients by PCR but not by Southern blotting. Immunohistochemistry demonstrated that 8-hydroxy-deoxyguanosine (8-OH-dG) and 4-hydroxy-2-nonenal were intensely stained in skeletal muscles of these patients particularly in RRFs. High-performance liquid chromatography with electrochemical detection analysis revealed an increase in 8-OH-dG from mitochondrial DNA. These findings may suggest that long-term corticosteroid administration potentially induces oxidative stress-mediated mitochondrial damage, resulting in the development of the oculoskeletal symptoms in some patients.  (日)    [継承]
キーワード (推奨): 1. (英) Aldehydes (日) (読) [継承]
2. (英) Anti-Inflammatory Agents (日) (読) [継承]
3. (英) Deoxyguanosine (日) (読) [継承]
4. (英) Diagnosis, Differential (日) (読) [継承]
5. (英) Exercise Test (日) (読) [継承]
6. (英) Female (日) (読) [継承]
7. (英) Gene Deletion (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Lactic Acid (日) (読) [継承]
10. (英) Male (日) (読) [継承]
11. (英) Middle Aged (日) (読) [継承]
12. (英) Mitochondria, Muscle (日) (読) [継承]
13. (英) Oculomotor Muscles (日) (読) [継承]
14. (英) Ophthalmoplegia, Chronic Progressive External (日) (読) [継承]
15. (英) Prednisolone (日) (読) [継承]
16. (英) Superoxide Dismutase (日) (読) [継承]
17. (英) Time Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Acta Neuropathologica (World Federation of Neurology)
(pISSN: 0001-6322, eISSN: 1432-0533)

ISSN (任意): 0001-6322
ISSN: 0001-6322 (pISSN: 0001-6322, eISSN: 1432-0533)
Title: Acta neuropathologica
Title(ISO): Acta Neuropathol
Supplier: Springer Online Journal Archive
Publisher: Springer Berlin Heidelberg
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 104 [継承]
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(必須): 260 266 [継承]
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年月日 (必須): 西暦 2002年 9月 初日 (平成 14年 9月 初日) [継承]
URL (任意):
DOI (任意): 10.1007/s00401-002-0553-5    (→Scopusで検索) [継承]
PMID (任意): 12172911    (→Scopusで検索) [継承]
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WOS (任意): 000177681600006 [継承]
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備考 (任意): 1.(英) Article.Affiliation: First Department of Internal Medicine, School of Medicine, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. tmitsui@clin.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Case Reports  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Takao Mitsui, Yoshifumi Umaki, Masakazu Nagasawa, Masashi Akaike, Kenji Aki, Hiroyuki Azuma, Shuji Ozaki, Masaaki Odomi and Toshio Matsumoto : Mitochondrial damage in patients with long-term corticosteroid therapy: development of oculoskeletal symptoms similar to mitochondrial disease, Acta Neuropathologica, Vol.104, No.3, 260-266, 2002.
欧文冊子 ● Takao Mitsui, Yoshifumi Umaki, Masakazu Nagasawa, Masashi Akaike, Kenji Aki, Hiroyuki Azuma, Shuji Ozaki, Masaaki Odomi and Toshio Matsumoto : Mitochondrial damage in patients with long-term corticosteroid therapy: development of oculoskeletal symptoms similar to mitochondrial disease, Acta Neuropathologica, Vol.104, No.3, 260-266, 2002.

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