『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Saika Mieko (日) (読)
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学籍番号 (推奨):
[継承]
2.井上 大輔
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[継承]
3. (英) Kido Shinsuke (日) (読)
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4.松本 俊夫
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題名 (必須): (英) 17β-Estradiol stimulates expression of osteoprotegerin by a mouse stromal cell line, ST-2, via estrogen receptor-α  (日)    [継承]
副題 (任意):
要約 (任意): (英) Osteoprotegerin (OPG) is a recently identified member of the tumor necrosis factor (TNF) receptor superfamily that regulates bone mass through an inhibitory action on osteoclast differentiation and function. To determine its potential roles of OPG in pathological changes in bone metabolism caused by estrogen deficiency, we investigated effects of estrogen on OPG expression by a mouse stromal cell line, ST-2, in vitro. Treatment of ST-2 cells with 17beta-E(2) resulted in up-regulation of OPG expression at both the messenger RNA and protein levels. The effect was time and dose dependent and steroid specific. The stimulatory action of 17beta-E(2) on OPG expression appeared to be mediated by the estrogen receptor-alpha (ERalpha) subtype because stable overexpression of ERalpha, but not of ERbeta, enhanced the OPG induction by 17beta-E(2). Moreover, estrogen withdrawal after 5-day pretreatment, mimicking the event occurring in vivo at menopause, dramatically diminished the expression of OPG. These findings suggest that down-regulation of OPG after estrogen withdrawal contributes to the enhanced osteoclastic bone resorption and bone loss after menopause by enhancing RANK ligand-RANK system that lies downstream of a large number of bone-resorbing cytokines.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Cell Line (日) (読) [継承]
3. (英) Dose-Response Relationship, Drug (日) (読) [継承]
4. (英) Estradiol (日) (読) [継承]
5. (英) Estrogen Receptor alpha (日) (読) [継承]
6.遺伝子発現 (gene expression) [継承]
7. (英) Glycoproteins (日) (読) [継承]
8. (英) Humans (日) (読) [継承]
9. (英) Kinetics (日) (読) [継承]
10. (英) Mice (日) (読) [継承]
11. (英) Osteoprotegerin (日) (読) [継承]
12. (英) RNA, Messenger (日) (読) [継承]
13. (英) Receptors, Cytoplasmic and Nuclear (日) (読) [継承]
14. (英) Receptors, Estrogen (日) (読) [継承]
15. (英) Receptors, Tumor Necrosis Factor (日) (読) [継承]
16. (英) Stromal Cells (日) (読) [継承]
発行所 (推奨): The Endocrine Society [継承]
誌名 (必須): Endocrinology ([The Endocrine Society])
(pISSN: 0013-7227, eISSN: 1945-7170)

ISSN (任意): 0013-7227
ISSN: 0013-7227 (pISSN: 0013-7227, eISSN: 1945-7170)
Title: Endocrinology
Title(ISO): Endocrinology
Publisher: Endocrine Society
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 142 [継承]
(必須): 6 [継承]
(必須): 2205 2212 [継承]
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年月日 (必須): 西暦 2001年 6月 初日 (平成 13年 6月 初日) [継承]
URL (任意):
DOI (任意): 10.1210/endo.142.6.8220    (→Scopusで検索) [継承]
PMID (任意): 11356664    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-85047681459 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Mieko Saika, Daisuke Inoue, Shinsuke Kido and Toshio Matsumoto : 17β-Estradiol stimulates expression of osteoprotegerin by a mouse stromal cell line, ST-2, via estrogen receptor-α, Endocrinology, Vol.142, No.6, 2205-2212, 2001.
欧文冊子 ● Mieko Saika, Daisuke Inoue, Shinsuke Kido and Toshio Matsumoto : 17β-Estradiol stimulates expression of osteoprotegerin by a mouse stromal cell line, ST-2, via estrogen receptor-α, Endocrinology, Vol.142, No.6, 2205-2212, 2001.

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