『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=130374EID:130374, Map:0, LastModified:2017年12月4日(月) 14:06:51, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[有持 秀喜], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1.有持 秀喜 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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2. (英) Kinouchi Takemi (日) (読) きのうち たけみ
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3.片岡 佳子 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.医用検査学系.微生物・遺伝子解析学])
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4.桑原 知巳
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5.大西 克成
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題名 (必須): (英) Activation of 1-nitropyrene by nitroreductase increases the DNA adduct level and mutagenicity  (日)    [継承]
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要約 (任意): (英) 1-Nitropyrene (1-NP) is a mutagenic nitro compound in the environment. We studied correlations between the mutagenicity of 1-NP for three strains of Salmonella typhimurium, the activity of bacterial nitroreductases and the amount of 1-NP-derived DNA adducts. Bacterial strains used in this study were S. typhimurium strains TA98, nitroreductase-less mutant TA98NR and YG1021 carrying a nitroreductase-producing plasmid. The mutagenicity of 1-NP was measured using the Ames assay, and the nitroreductase activities of these strains were assayed by quantification of 1-aminopyrene produced from 1-NP. The DNA adducts were measured by the 32P-postlabeling method. Among the three bacterial strains, strain YG1021 was the highest in mutagenicity of 1-NP, the nitroreductase activity and the DNA adduct level. However, S. typhimurium strain TA98NR had the lowest values of these three parameters. Nitroreductase activity, DNA adduct level and mutagenicity were strongly correlated with each other. These results indicate that bacterial nitroreductase plays an important role in forming the DNA adducts, and that the higher the adduct level the higher the level of mutagenicity.  (日)    [継承]
キーワード (推奨): 1. (英) Salmonella typhimurium (日) (読) [継承]
2. (英) 1-nitropyrene (日) (読) [継承]
3. (英) nitroreductase activity (日) (読) [継承]
4. (英) DNA adduct (日) (読) [継承]
5. (英) mutagenicity (日) (読) [継承]
発行所 (推奨): 徳島大学.医学部 [継承]
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
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年月日 (必須): 西暦 1997年 12月 10日 (平成 9年 12月 10日) [継承]
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PMID (任意): 9597808    (→Scopusで検索) [継承]
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機関リポジトリ : 110666 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Hideki Arimochi, Takemi Kinouchi, Keiko Kataoka, Tomomi Kuwahara and Yoshinari Ohnishi : Activation of 1-nitropyrene by nitroreductase increases the DNA adduct level and mutagenicity, The Journal of Medical Investigation : JMI, Vol.44, No.3-4, 193-198, 1997.
欧文冊子 ● Hideki Arimochi, Takemi Kinouchi, Keiko Kataoka, Tomomi Kuwahara and Yoshinari Ohnishi : Activation of 1-nitropyrene by nitroreductase increases the DNA adduct level and mutagenicity, The Journal of Medical Investigation : JMI, Vol.44, No.3-4, 193-198, 1997.

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