『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Bunpo Piyawan (日) (読)
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2.片岡 佳子 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.医用検査学系.微生物・遺伝子解析学])
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3.有持 秀喜 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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4.中山 治之
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5.桑原 知巳
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6.坂東 良美 ([徳島大学.病院.中央診療施設等.病理部])
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7.泉 啓介
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8. (英) Vinitketkumnuen Usanee (日) (読)
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9.大西 克成
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題名 (必須): (英) Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats  (日)    [継承]
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要約 (任意): (英) Effects of the water extract of Centella asiatica Linn. on formation of azoxymethane (AOM)-induced aberrant crypt foci (ACF) and intestinal tumorigenesis in male F344 rats were investigated. Treatment with the extract significantly decreased the number of larger ACF (with four or more crypts per focus) in the large intestine in the early stage, while the number of methylated DNA adducts was not decreased compared with that in the AOM-treated group. In the post-initiation stage, the extract significantly decreased the total number of ACF and the number of larger ACF, accompanied by a decrease in the 5-bromo-2'-deoxyuridine-labeling index and an increase in the induction of apoptotic cells in the colonic mucosa. The incidences of neoplasms, the numbers of adenocarcinomas in the small intestines and entire intestines, and sizes of neoplasms in the entire intestines in rats fed C. asiatica extract at a dose of 10 mg/kg were smaller than those in rats given AOM alone (p < 0.05). The extract at a dose of 100 mg/kg significantly reduced the multiplicity of neoplasms in the small intestine (p < 0.05). These results suggest that inhibition of the formation of AOM-induced ACF by C. asiatica extract is associated with modification of cell proliferation and induction of apoptosis in colonic crypts and that the extract has a chemopreventive effect on colon tumorigenesis.  (日)    [継承]
キーワード (推奨): 1. (英) Azoxymethane (AOM) (日) (読) [継承]
2. (英) Aberrant crypt foci (ACF) (日) (読) [継承]
3. (英) Intestinal tumor (日) (読) [継承]
4. (英) Centella asiatica (日) (読) [継承]
5. (英) Cell proliferation (日) (読) [継承]
6.アポトーシス (apoptosis) [継承]
発行所 (推奨): Elsevier (->組織[Elsevier Science]) [継承]
誌名 (必須): Food and Chemical Toxicology (British Industrial Biological Research Association)
(pISSN: 0278-6915, eISSN: 1873-6351)

ISSN (任意): 0278-6915
ISSN: 0278-6915 (pISSN: 0278-6915, eISSN: 1873-6351)
Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Title(ISO): Food Chem Toxicol
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 42 [継承]
(必須): 12 [継承]
(必須): 1987 1997 [継承]
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年月日 (必須): 西暦 2004年 12月 初日 (平成 16年 12月 初日) [継承]
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DOI (任意): 10.1016/j.fct.2004.06.022    (→Scopusで検索) [継承]
PMID (任意): 15500935    (→Scopusで検索) [継承]
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WOS (任意): 000225252500008 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Bacteriology, Graduate School of Medicine, The University of Tokushima, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Piyawan Bunpo, Keiko Kataoka, Hideki Arimochi, Haruyuki Nakayama, Tomomi Kuwahara, Yoshimi Bando, Keisuke Izumi, Usanee Vinitketkumnuen and Yoshinari Ohnishi : Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats, Food and Chemical Toxicology, Vol.42, No.12, 1987-1997, 2004.
欧文冊子 ● Piyawan Bunpo, Keiko Kataoka, Hideki Arimochi, Haruyuki Nakayama, Tomomi Kuwahara, Yoshimi Bando, Keisuke Izumi, Usanee Vinitketkumnuen and Yoshinari Ohnishi : Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats, Food and Chemical Toxicology, Vol.42, No.12, 1987-1997, 2004.

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