『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=127961EID:127961, Map:0, LastModified:2013年6月21日(金) 21:01:06, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[片岡 佳子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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著者 (必須): 1. (英) Nakanishi Shuusuke (日) (読)
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2.片岡 佳子 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.医用検査学系.微生物・遺伝子解析学])
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3.桑原 知巳
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4.大西 克成
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題名 (必須): (英) Effects of high amylose maize starch and Clostridium butyricum on metabolism in colonic microbiota and formation of azoxymethane-induced aberrant crypt foci in the rat colon  (日)    [継承]
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要約 (任意): (英) High amylose maize starch (HAS) is not digested in the small intestine and most of it reaches the large intestine. In the large intestine, HAS is fermented by intestinal bacteria, resulting in production of short-chain fatty acids (SCFA), particularly butyrate. Clostridium butyricum can utilize HAS and produce butyrate and acetate. It has been proposed that butyrate inhibits carcinogenesis in the colon. In this study, we examined the inhibitory effects of HAS and C. butyricum strain MIYAIRI588 (CBM588) on azoxymethane-induced aberrant crypt foci (ACF) formation in rats. In the group of rats administered only CBM588 spores, the concentration of butyrate in the cecum increased, but there was no decrease in the number of ACF. In the group of rats fed an HAS diet, a decrease in the number of ACF was observed, and in the group of rats administered HAS and CBM588, the number of ACF decreased significantly. In these two groups, the concentrations of acetate and propionate in intestinal contents significantly increased, but the concentration of butyrate did not change. It was found that the beta-glucuronidase activity level of colonic contents decreased significantly in the two groups of rats fed HAS. This study showed that HAS and CBM588 changed the metabolism of colonic microbiota and decreased the level of beta-glucuronidase activity, phenomena that may play a role in the inhibition of ACF formation in the rat colon.  (日)    [継承]
キーワード (推奨): 1. (英) Clostridium butyricum (日) (読) [継承]
2. (英) High amylose starch (日) (読) [継承]
3. (英) Azoxymethane (日) (読) [継承]
4. (英) Aberrant crypt foci (日) (読) [継承]
発行所 (推奨): (英) Japanese Society for Bacteriology,Japanese Society for Virology,Japanese Society for Immunology (日) (読) [継承]
誌名 (必須): Microbiology and Immunology ([日本細菌学会])
(pISSN: 0385-5600, eISSN: 1348-0421)

ISSN (任意): 0385-5600
ISSN: 0385-5600 (pISSN: 0385-5600, eISSN: 1348-0421)
Title: Microbiology and immunology
Title(ISO): Microbiol Immunol
Supplier: 財団法人 学会誌刊行センター
Publisher: Wiley Publishing
 (NLM Catalog  (医中誌Web  (J-STAGE  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 2003年 0月 初日 (平成 15年 0月 初日) [継承]
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PMID (任意): 14695445    (→Scopusで検索) [継承]
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WOS (任意): 000187042000008 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Bacteriology, Graduate School of Medicine, The University of Tokushima, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Shuusuke Nakanishi, Keiko Kataoka, Tomomi Kuwahara and Yoshinari Ohnishi : Effects of high amylose maize starch and Clostridium butyricum on metabolism in colonic microbiota and formation of azoxymethane-induced aberrant crypt foci in the rat colon, Microbiology and Immunology, Vol.47, No.12, 951-958, 2003.
欧文冊子 ● Shuusuke Nakanishi, Keiko Kataoka, Tomomi Kuwahara and Yoshinari Ohnishi : Effects of high amylose maize starch and Clostridium butyricum on metabolism in colonic microbiota and formation of azoxymethane-induced aberrant crypt foci in the rat colon, Microbiology and Immunology, Vol.47, No.12, 951-958, 2003.

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