『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=127957)

EID=127957EID:127957, Map:0, LastModified:2017年12月4日(月) 14:06:41, Operator:[[ADMIN]], Avail:TRUE, Censor:0, Owner:[片岡 佳子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Intiyot Yaowarate (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Kinouchi Takemi (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.片岡 佳子 ([徳島大学.大学院医歯薬学研究部.保健学域.保健科学部門.医用検査学系.微生物・遺伝子解析学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.有持 秀喜 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.桑原 知巳
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6. (英) Vinitketkumnuen Usanee (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.大西 克成
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Antimutagenicity of Murdannia loriformis in the Salmonella mutation assay and its inhibitory effects on azoxymethane-induced DNA methylation and aberrant crypt focus formation in male F344 rats  (日)    [継承]
副題 (任意):
要約 (任意): (英) An 80% ethanol extract of Murdannia loriformis, a Thai medicinal plant, was examined for antimutagenic activity and cancer chemopreventive activity. In the Salmonella mutation assay, the extract showed antimutagenicity against 2-amino-3-methylimidazo [4,5-f]quinoline, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline, 2-amino-3,8-dimethylimidazo [4,5-f]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 2-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole, 3-amino-1-methyl-5H-pyrido[4,3-b]indole, 2-amino-6-methyldipyrido [1,2-a:3',2'-d] imidazole, 2-aminodipyrido[1,2-a:3',2'-d]imidazole, 2-aminoanthracene, 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide, N-methyl-N'-nitro-N-nitrosoguanidine and methylazoxymethanol acetate and reduced their mutagenicities to 31.4-67.9% at the dose of 10 mg/plate. However, it did not inhibit the mutagenicities of 2-amino-9H-pyrido[2,3-b]indole, 2-amino-3-methyl-9 H-pyrido[2,3-b]indole, benzo[a]pyrene,N-ethyl-N'-nitro-N-nitrosoguanidine and 1-nitropyrene. The extract itself showed no mutagenicity. The chemopreventive activity of M. loriformis was examined using azoxymethane (AOM)-induced aberrant crypt focus (ACF) formation in the colon of F344 rats. The extract at doses of 0.1-1.0 g/kg wt significantly inhibited ACF formation in the initiation stage (21-51%), although it was more effective at a lower dose. In the post-initiation stage, the extract also tended to inhibit ACF formation (12-27%) and significantly decreased the number of larger ACFs that have more than 3 aberrant crypts per focus. The extract inhibited the formation of O6-methylguanine and N7-methylguanine in the colonic mucosa and muscular layers but not or increased in the liver. These results indicate that M. loriformis extract has antimutagenic activity toward various known mutagens and that it inhibits AOM-induced ACF formation both in the initiation and post-initiation stages in the rat colon.  (日)    [継承]
キーワード (推奨): 1. (英) Murdannia loriformis (日) (読) [継承]
2. (英) antimutagenicity (日) (読) [継承]
3. (英) azoxymethane-induced aberrant crypt foci (日) (読) [継承]
4. (英) O6-methylguanine (日) (読) [継承]
発行所 (推奨): 徳島大学.医学部 [継承]
誌名 (必須): The Journal of Medical Investigation : JMI ([徳島大学.医学部])
(pISSN: 1343-1420, eISSN: 1349-6867)

ISSN (任意): 1343-1420
ISSN: 1343-1420 (pISSN: 1343-1420, eISSN: 1349-6867)
Title: The journal of medical investigation : JMI
Title(ISO): J Med Invest
Supplier: 徳島大学
Publisher: Tokushima Daigaku Igakubu
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 49 [継承]
(必須): 1,2 [継承]
(必須): 25 34 [継承]
都市 (任意):
年月日 (必須): 西暦 2002年 2月 初日 (平成 14年 2月 初日) [継承]
URL (任意):
DOI (任意):
PMID (任意): 11901756    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
機関リポジトリ : 110631 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Bacteriology, University of Tokushima School of Medicine, Kuramoto-cho, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]

標準的な表示

和文冊子 ● Yaowarate Intiyot, Takemi Kinouchi, Keiko Kataoka, Hideki Arimochi, Tomomi Kuwahara, Usanee Vinitketkumnuen and Yoshinari Ohnishi : Antimutagenicity of Murdannia loriformis in the Salmonella mutation assay and its inhibitory effects on azoxymethane-induced DNA methylation and aberrant crypt focus formation in male F344 rats, The Journal of Medical Investigation : JMI, Vol.49, No.1,2, 25-34, 2002.
欧文冊子 ● Yaowarate Intiyot, Takemi Kinouchi, Keiko Kataoka, Hideki Arimochi, Tomomi Kuwahara, Usanee Vinitketkumnuen and Yoshinari Ohnishi : Antimutagenicity of Murdannia loriformis in the Salmonella mutation assay and its inhibitory effects on azoxymethane-induced DNA methylation and aberrant crypt focus formation in male F344 rats, The Journal of Medical Investigation : JMI, Vol.49, No.1,2, 25-34, 2002.

関連情報

Number of session users = 0, LA = 1.45, Max(EID) = 375577, Max(EOID) = 1006386.