| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Okuda M. (日) (読)
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| ○学籍番号 (推奨): |
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| 2. | (英) Iida A. (日) (読)
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| ○貢献度 (任意): |
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| 3. | 高石 喜久
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Fungal Metabolites X. The effect of Peptide Antibiotics, Trichosporins-Bs, on the Respiratory Activity of Mitochondria (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The effect of the trichosporin-Bs, peptide antibiotics, on the respiration of mitochondria was investigated. Trichosporin-Bs stimulated the respiratory rate of state 4 rat liver mitochondria in a dose-dependent manner. The maximum respiratory rate obtained by trichosporin-Bs was essentially the same as for 2,4-dinitrophenol and SF6847. Trichosporin-B-VIb released oligomycin-inhibited respiration of mitochondria. This means that trichosporin-Bs are uncouplers of oxidative phosphorylation. The stimulatory effect of trichosporin-B-VIb, a component of trichosporin-Bs, on mitochondrial respiration was increased by inorganic phosphate but not by other permeant anions studied. These results suggest that the stimulation of mitochondrial respiration by trichosporin-B-VIb is mediated by the same mechanism as is operating in the case of hypelcins and alamethicins. Furthermore, the relative potencies of trichosporin-Bs on the mitochondrial respiration and their relative hydrophobicities were examined. A clear relationship was observed between the uncoupling potencies of trichosporin-Bs and their relative hydrophobicities. (日)
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| ○キーワード (推奨): | 1. | (英) 2,4-Dinitrophenol (日) (読)
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| 2. | (英) Amino Acid Sequence (日) (読)
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| 3. | (英) Animals (日) (読)
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| 4. | (英) Anti-Bacterial Agents (日) (読)
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| 5. | (英) Cell Fractionation (日) (読)
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| 6. | (英) Dinitrophenols (日) (読)
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| 7. | (英) Dose-Response Relationship, Drug (日) (読)
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| 8. | (英) Drug Interactions (日) (読)
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| 9. | (英) Mitochondria, Liver (日) (読)
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| 10. | (英) Molecular Sequence Data (日) (読)
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| 11. | (英) Nitriles (日) (読)
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| 12. | (英) Oligomycins (日) (読)
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| 13. | 酸化的リン酸化 (oxidative phosphorylation)
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| 14. | 酸素消費 (oxygen consumption)
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| 15. | (英) Peptides (日) (読)
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| 16. | (英) Phosphates (日) (読)
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| 17. | (英) Rats (日) (読)
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| 18. | (英) Uncoupling Agents (日) (読)
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| ○発行所 (推奨): | □ | 日本薬学会
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| ○誌名 (必須): | □ | Biological & Pharmaceutical Bulletin ([日本薬学会])
(pISSN: 0918-6158, eISSN: 1347-5215)
| ○ISSN (任意): | □ | 0918-6158
ISSN: 0918-6158
(pISSN: 0918-6158, eISSN: 1347-5215) Title: Biological & pharmaceutical bulletinTitle(ISO): Biol Pharm BullSupplier: 公益社団法人日本薬学会Publisher: Pharmaceutical Society of Japan (NLM Catalog)
(CiNii NCID)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 17
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 482 485
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1994年 4月 初日 (平成 6年 4月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1248/bpb.17.482 (→Scopusで検索)
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| ○PMID (任意): | □ | 8069252 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-0028266268
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| ○researchmap (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Comparative Study (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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