| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Hayashi Kyoko (日) (読)
| ○役割 (任意): |
| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) Hayashi Toshimitsu (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 3. | (英) Ujita Kunie (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 4. | 高石 喜久
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Characterization of antiviral activity of a sesquiterpene, triptofordin C-2 (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The activities of 13 sesquiterpenes isolated from Tripterygium wilfordii Hook fil. var. regelii Makino were studied against herpes simplex virus type 1 (HSV-1) in vitro. Among these compounds, only triptofordin C-2 showed a selectivity index of more than 10. The compound, which could also inhibit the replication of human cytomegalovirus (HCMV), did not affect either adsorption or penetration of HSV-1 to host cells, but showed moderate virucidal activity against several enveloped viruses including HSV-1, HCMV, measles virus and influenza A virus. Triptofordin C-2 suppressed viral protein synthesis of infected cells when added at early steps of HSV-1 replication and exerted inhibition of translation of the transcripts of the immediate early genes. When acyclovir and triptofordin C-2 were evaluated in combination for antiviral activity against HSV-1 replication, additive antiviral effects were observed for this virus. (日)
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| ○キーワード (推奨): | 1. | (英) Acyclovir (日) (読)
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| 2. | 吸着 (adsorption)
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| 3. | (英) Antiviral Agents (日) (読)
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| 4. | 細胞分裂 (cell division)
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| 5. | (英) Cell Line (日) (読)
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| 6. | (英) Drug Interactions (日) (読)
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| 7. | (英) Drugs, Chinese Herbal (日) (読)
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| 8. | (英) HeLa Cells (日) (読)
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| 9. | (英) Humans (日) (読)
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| 10. | (英) In Vitro Techniques (日) (読)
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| 11. | (英) Sesquiterpenes (日) (読)
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| 12. | (英) Simplexvirus (日) (読)
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| 13. | (英) Virus Replication (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Antimicrobial Chemotherapy (The British Society for Antimicrobial Chemotherapy)
(pISSN: 0305-7453, eISSN: 1460-2091)
| ○ISSN (任意): | □ | 0305-7453
ISSN: 0305-7453
(pISSN: 0305-7453, eISSN: 1460-2091) Title: The Journal of antimicrobial chemotherapyTitle(ISO): J Antimicrob ChemotherSupplier: Oxford University PressPublisher: Oxford University Press (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 37
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 759 768
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1996年 4月 初日 (平成 8年 4月 初日)
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| ○URL (任意): | □ | http://jac.oxfordjournals.org/cgi/content/abstract/37/4/759
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| ○DOI (任意): | □ | 10.1093/jac/37.4.759 (→Scopusで検索)
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| ○PMID (任意): | □ | 8722541 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-0029978212
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| ○researchmap (任意): |
| ○評価値 (任意): |
| ○被引用数 (任意): |
| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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