| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Yesilada Erdem (日) (読)
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| 2. | 高石 喜久
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| 3. | (英) Fujita Tetsuro (日) (読)
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| 4. | (英) Sezik Ekrem (日) (読)
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| ○題名 (必須): | □ | (英) Anti-ulcerogenic effects of Spartium junceum flowers on in vivo test models in rats (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Flowers of Spartium junceum L. (Fabaceae) are used for the treatment of gastric ulcers in Turkish folk medicine. Through bioassay-guided fractionation using chemical and chromatographical means and water immersion and restraint-induced stress ulcer model in rats, a saponin fraction was determined as the potent anti-ulcerogenic ingredient. The active fraction was also highly effective in preventing ethanol- and pyloric ligation-induced gastric lesions as well as inhibiting gastric secretion volume, gastric pH and titratable acidity, but did not affect the hexosamine content of the gastric mucosa. A novel oleanen-type triterpenic saponin, named as spartitrioside, was isolated as the active principle by using chromatographical separation techniques. (日)
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| ○キーワード (推奨): | 1. | (英) Spartium junceum L. (日) (読)
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| 2. | (英) Fabaceae (日) (読)
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| 3. | (英) Anti-ulcerogenic activity (日) (読)
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| 4. | (英) Water-immersion and restraint-induced stress ulcer (日) (読)
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| 5. | (英) Ethanol-induced ulcer (日) (読)
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| 6. | (英) Pyloric ligation-induced ulcer (日) (読)
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| 7. | (英) Gastric secretion (日) (読)
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| 8. | (英) Hexosamine level (日) (読)
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| 9. | (英) Oleanene-type saponin (日) (読)
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| 10. | (英) Spartitrioside (日) (読)
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| ○発行所 (推奨): | □ | (英) Elsevier Science Ireland Ltd. (日) (読)
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| ○誌名 (必須): | □ | Journal of Ethnopharmacology ([Elsevier Science])
(pISSN: 0378-8741, eISSN: 1872-7573)
| ○ISSN (任意): | □ | 0378-8741
ISSN: 0378-8741
(pISSN: 0378-8741, eISSN: 1872-7573) Title: Journal of ethnopharmacologyTitle(ISO): J EthnopharmacolPublisher: Elsevier Ireland Ltd (NLM Catalog)
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(CrossRef)
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| ○巻 (必須): | □ | 70
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 219 226
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2000年 7月 15日 (平成 12年 7月 15日)
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| ○URL (任意): | □ | http://dx.doi.org/10.1016/S0378-8741(99)00180-4
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| ○DOI (任意): | □ | 10.1016/S0378-8741(99)00180-4 (→Scopusで検索)
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| ○PMID (任意): | □ | 10837986 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS : | □ | 000088270600005
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| ○Scopus (任意): | 1. | 2-s2.0-0343183288
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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