| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Nagase Masahiro (日) (読)
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| 2. | (英) Oto Jinsei (日) (読)
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| 3. | (英) Sugiyama Sin (日) (読)
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| 4. | (英) Yube Kouichi (日) (読)
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| 5. | 高石 喜久 ([徳島大学.デザイン型AI教育研究センター])
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| 6. | (英) Sakato Nobuo (日) (読)
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| ○題名 (必須): | □ | (英) Apoptosis Induction in HL-60 Cells and Inhibition of Topoisomerase II by Triterpene Celastrol (日)
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| ○要約 (任意): | □ | (英) Celastrol, which is a triterpene purified from Celastraceae plants, has anticancer and anti-inflammatory activities. In this study we investigated to clarify whether celastrol can induce apoptosis in a human leukemia HL-60 model system. Celastrol was found to induce apoptosis, and the rank order of the potency of celastrol and its derivatives to induce internucleosomal DNA fragmentation was found to be celastrol>cela-H>the other derivatives=vehicle control. Many anticancer agents are known to possess the ability to inhibit topoisomerase II, so the inhibitory activities of celastrol and its derivatives on topoisomerase II were also explored. The rank order of the inhibitory activity was found to be celastrol>etoposide>cela-H, indicating that the apoptosis-inducing activities of cela derivatives correspond to their inhibitory activities on topoisomerase II. These data suggested that celastrol may cause its effects such as anticancer activity by the mechanism of apoptosis along with topoisomerase II inhibition. (日)
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| ○キーワード (推奨): | 1. | (英) Antineoplastic Agents, Phytogenic (日) (読)
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| 2. | (英) Apoptosis (日) (読)
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| 3. | (英) DNA Fragmentation (日) (読)
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| 4. | (英) Dose-Response Relationship, Drug (日) (読)
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| 5. | (英) Enzyme Inhibitors (日) (読)
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| 6. | (英) Etoposide (日) (読)
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| 7. | (英) Flow Cytometry (日) (読)
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| 8. | (英) HL-60 Cells (日) (読)
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| 9. | (英) Humans (日) (読)
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| 10. | (英) Inhibitory Concentration 50 (日) (読)
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| 11. | (英) Molecular Structure (日) (読)
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| 12. | (英) Time Factors (日) (読)
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| 13. | (英) Topoisomerase II Inhibitors (日) (読)
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| 14. | (英) Triterpenes (日) (読)
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| ○発行所 (推奨): | □ | 社団法人 日本農芸化学会
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| ○誌名 (必須): | □ | Bioscience, Biotechnology, and Biochemistry ([社団法人 日本農芸化学会])
(pISSN: 0916-8451, eISSN: 1347-6947)
| ○ISSN (任意): | □ | 0916-8451
ISSN: 0916-8451
(pISSN: 0916-8451, eISSN: 1347-6947) Title: Bioscience, biotechnology, and biochemistryTitle(ISO): Biosci Biotechnol BiochemSupplier: 社団法人日本農芸化学会Publisher: Oxford University Press (NLM Catalog)
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| ○巻 (必須): | □ | 67
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| ○号 (必須): | □ | 9
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| ○頁 (必須): | □ | 1883 1887
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| ○年月日 (必須): | □ | 西暦 2003年 9月 初日 (平成 15年 9月 初日)
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| ○URL (任意): | □ | http://www.jsbba.or.jp/e/e_05/bbb6709e.html#5
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| ○DOI (任意): | □ | 10.1271/bbb.67.1883 (→Scopusで検索)
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| ○PMID (任意): | □ | 14519971 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Life Sciences, Faculty of Agriculture, Kagawa University, Miki, Japan. nagase@ag.kagawa-u.ac.jp (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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