| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.創薬資源科学部門.資源分子探索学講座 (2004年4月1日〜)
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| ○著者 (必須): | 1. | 小暮 健太朗 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.創薬科学系.衛生薬学])
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| 2. | 山内 あい子
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| 3. | 德村 彰
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| 4. | (英) Kondou Kyoko (日) (読)
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| 5. | 田中 直伸 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.生薬学])
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| 6. | 高石 喜久 ([徳島大学.デザイン型AI教育研究センター])
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| 7. | 福澤 健治
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| ○題名 (必須): | □ | (英) Novel antioxidants isolated from plants of the genera Ferula, Inula, Prangos and Rheum collected in Uzbekistan (日)
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| ○要約 (任意): | □ | (英) We examined the effects of 48 compounds isolated from Ferula pallida, F. penninervis, Inula macrophylla, Prangos pabularia, P. tschimganica and Rheum maximowiczii collected in Uzbekistan on ADP/Fe2+-induced lipid peroxidation of egg yolk phosphatidylcholine liposomes. Of those compounds, 23 inhibited ADP/Fe2+-induced lipid peroxidation and nine showed especially strong inhibition of lipid peroxidation. Most compounds that inhibited peroxidation scavenged the 1,1'-diphenyl-2-picrylhydrazyl (DPPH) radical, indicating that the inhibition was due to radical scavenging. However, some compounds did not scavenge DPPH but inhibited lipid peroxidation significantly, suggesting that their inhibitory effect was not due to radical scavenging but to some other mechanism, such as prevention of Fe2+ function. Thus, we found various new antioxidants, some of which had a unique mechanism of action, in Ferula, Inula, Prangos and Rheum plants collected in Uzbekistan as seeds used in medicine. (日)
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| ○キーワード (推奨): | 1. | (英) Antioxidants (日) (読)
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| 2. | (英) Natural products (日) (読)
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| 3. | (英) Ferula (日) (読)
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| 4. | (英) Inula (日) (読)
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| 5. | (英) Prangos (日) (読)
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| 6. | (英) Rheum (日) (読)
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| ○発行所 (推奨): | □ | (英) Elsevier GmbH (日) (読)
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| ○誌名 (必須): | □ | Phytomedicine ([Elsevier])
(pISSN: 0944-7113, eISSN: 1618-095X)
| ○ISSN (任意): | □ | 0944-7113
ISSN: 0944-7113
(pISSN: 0944-7113, eISSN: 1618-095X) Title: Phytomedicine : international journal of phytotherapy and phytopharmacologyTitle(ISO): PhytomedicinePublisher: Elsevier GmbH (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 11
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| ○号 (必須): | □ | 7-8
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| ○頁 (必須): | □ | 645 651
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| ○年月日 (必須): | □ | 西暦 2004年 11月 25日 (平成 16年 11月 25日)
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| ○URL (任意): | □ | http://dx.doi.org/10.1016/j.phymed.2003.09.004
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| ○DOI (任意): | □ | 10.1016/j.phymed.2003.09.004 (→Scopusで検索)
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| ○PMID (任意): | □ | 15636179 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000226315400012
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi-1, 770-8505 Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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