| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.創薬資源科学部門.資源分子探索学講座 (2004年4月1日〜)
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| ○著者 (必須): | 1. | 柴田 洋文
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| 2. | (英) Kondo Kyoko (日) (読)
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| 3. | (英) Katsuyama Ryo (日) (読)
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| 4. | 川添 和義
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| 5. | 佐藤 陽一 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品情報学])
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| 6. | (英) Murakami Kotaro (日) (読)
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| 7. | 高石 喜久 ([徳島大学.デザイン型AI教育研究センター])
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| 8. | 新垣 尚捷
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| 9. | 樋口 富彦
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| ○題名 (必須): | □ | (英) Alkyl Gallates, Intensifiers of ß-Lactam Susceptibility in Methicillin-Resistant Staphylococcus aureus (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) We found that ethyl gallate purified from a dried pod of tara (Caesalpinia spinosa) intensified beta-lactam susceptibility in methicillin-resistant and methicillin-sensitive strains of Staphylococcus aureus (MRSA and MSSA strains, respectively). This compound and several known alkyl gallates were tested with MRSA and MSSA strains to gain new insights into their structural functions in relation to antimicrobial and beta-lactam susceptibility-intensifying activities. The maximum activity of alkyl gallates against MRSA and MSSA strains occurred at 1-nonyl and 1-decyl gallate, with an MIC at which 90% of the isolates tested were inhibited of 15.6 microg/ml. At concentrations lower than the MIC, alkyl gallates synergistically elevated the susceptibility of MRSA and MSSA strains to beta-lactam antibiotics. Such a synergistic activity of the alkyl gallates appears to be specific for beta-lactam antibiotics, because no significant changes were observed in the MICs of other classes of antibiotics examined in this study. The length of the alkyl chain was also associated with the modifying activity of the alkyl gallates, and the optimum length was C5 to C6. The present work clearly demonstrates that the length of the alkyl chain has a key role in the elevation of susceptibility to beta-lactam antibiotics. (日)
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| ○キーワード (推奨): | 1. | (英) Anti-Bacterial Agents (日) (読)
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| 2. | (英) Drug Synergism (日) (読)
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| 3. | (英) Gallic Acid (日) (読)
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| 4. | (英) Magnetic Resonance Spectroscopy (日) (読)
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| 5. | (英) Methicillin Resistance (日) (読)
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| 6. | (英) Microbial Sensitivity Tests (日) (読)
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| 7. | (英) Plant Extracts (日) (読)
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| 8. | (英) Plants, Medicinal (日) (読)
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| 9. | (英) Spectrometry, Mass, Electrospray Ionization (日) (読)
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| 10. | (英) Staphylococcus aureus (日) (読)
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| 11. | (英) beta-Lactams (日) (読)
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| ○発行所 (推奨): | □ | アメリカ微生物学会
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| ○誌名 (必須): | □ | Antimicrobial Agents and Chemotherapy ([アメリカ微生物学会])
(pISSN: 0066-4804, eISSN: 1098-6596)
| ○ISSN (任意): | □ | 0066-4804
ISSN: 0066-4804
(pISSN: 0066-4804, eISSN: 1098-6596) Title: Antimicrobial agents and chemotherapyTitle(ISO): Antimicrob Agents ChemotherPublisher: American Society for Microbiology (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 49
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 549 555
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| ○年月日 (必須): | □ | 西暦 2005年 2月 初日 (平成 17年 2月 初日)
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| ○URL (任意): | □ | http://aac.asm.org/cgi/content/abstract/49/2/549
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| ○DOI (任意): | □ | 10.1128/AAC.49.2.549-555.2005 (→Scopusで検索)
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| ○PMID (任意): | □ | 15673731 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Molecular Cell Biology, Institute of Health Biosciences, The University of Tokushima, Shomachi, Tokushima 770-8505, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) OtherID: PMC547244 (日)
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