『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=126334EID:126334, Map:0, LastModified:2012年11月2日(金) 22:25:02, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.薬学部.薬学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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審査 (推奨): Peer Review [継承]
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組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.生体情報薬科学部門.薬物情報解析学講座 (2004年4月1日〜2015年3月31日) [継承]
著者 (必須): 1.姫田 敏樹
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2. (英) Mizuno Kumiko (日) 水野 くみ子 (読) みずの くみこ
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3. (英) Kato Hiroyuki (日) 加藤 宏之 (読) かとう ひろゆき
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4.荒木 勉
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題名 (必須): (英) Effects of age on immunohistochemical changes in the mouse hippocampus  (日)    [継承]
副題 (任意):
要約 (任意): (英) We investigated the age-related changes in neuronal cell death and synaptophysin of the hippocampal CA1 sector in mice using immunohistochemistry. Microtubule-associated protein 2a, b (MAP2) and synaptophysin immunoreactivity was measured in 2-, 8-, 18-, 42- and 59-week-old mice. MAP2 immunoreactivity was unchanged in the hippocampal CA1 sector up to 42 weeks after birth. In 59-week-old mice, however, a significant decrease in MAP2 immunoreactivity was observed in the hippocampal CA1 sector. Total number of synaptophysin-positive boutons was also unchanged in the hippocampal CA1 sector up to 42 weeks of birth. In 59-week-old mice, however, a significant increase in synaptophysin-positive boutons was observed in the hippocampal CA1 sector. These results demonstrate that dendrites and axons in the hippocampal CA1 neurons are particularly susceptible to ageing processes. In contrast, a marked increase in synaptophysin-positive boutons was found in the hippocampal CA1 sector of aged mice. These findings suggest that increase in synaptophysin-positive boutons may play a role in the maintenance of the structural components in the hippocampal CA1 sector of aged mice although most postsynaptic CA1 pyramidal neurons are generated. Thus, our findings provide further valuable information on age-related neurodegeneration and deficits in hippocampus-dependent memory and synaptic plasticity.  (日)    [継承]
キーワード (推奨): 1.加齢 (aging/->キーワード[老化]) [継承]
2.免疫組織化学 (immunohistochemistry) [継承]
3. (英) Synaptophysin (日) (読) [継承]
4. (英) Hippocampal CA1 neurons (日) (読) [継承]
5. (英) Mice (日) (読) [継承]
発行所 (推奨): Elsevier (->組織[Elsevier Science]) [継承]
誌名 (必須): Mechanisms of Ageing and Development (Elsevier Ireland Ltd)
(pISSN: 0047-6374, eISSN: 1872-6216)

ISSN (任意): 0047-6374
ISSN: 0047-6374 (pISSN: 0047-6374, eISSN: 1872-6216)
Title: Mechanisms of ageing and development
Title(ISO): Mech Ageing Dev
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 126 [継承]
(必須): 6-7 [継承]
(必須): 673 677 [継承]
都市 (任意): (英) Ireland (日) (読) [継承]
年月日 (必須): 西暦 2005年 6月 末日 (平成 17年 6月 末日) [継承]
URL (任意): http://dx.doi.org/10.1016/j.mad.2004.12.004 [継承]
DOI (任意): 10.1016/j.mad.2004.12.004    (→Scopusで検索) [継承]
PMID (任意): 15888321    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Drug Metabolism and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) MedlineDate: 2005 Jun-Jul  (日)    [継承]

標準的な表示

和文冊子 ● Toshiki Himeda, Kumiko Mizuno, Hiroyuki Kato and Tsutomu Araki : Effects of age on immunohistochemical changes in the mouse hippocampus, Mechanisms of Ageing and Development, Vol.126, No.6-7, 673-677, 2005.
欧文冊子 ● Toshiki Himeda, Kumiko Mizuno, Hiroyuki Kato and Tsutomu Araki : Effects of age on immunohistochemical changes in the mouse hippocampus, Mechanisms of Ageing and Development, Vol.126, No.6-7, 673-677, 2005.

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