『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=124402)

EID=124402EID:124402, Map:0, LastModified:2012年9月2日(日) 19:25:33, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[有持 秀喜], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.大学院ヘルスバイオサイエンス研究部.神経情報医学部門.病態情報医学講座 (2004年4月1日〜) [継承]
著者 (必須): 1.森田 恭二
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2.有持 秀喜 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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学籍番号 (推奨):
[継承]
3. (英) Her Song (日) (読)
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学籍番号 (推奨):
[継承]
題名 (必須): (英) Serotonergic 5-HT2A receptor stimulation induces steroid 5a-reductase gene expression in rat C6 glioma cells via transcription factor Egr-1  (日)    [継承]
副題 (任意):
要約 (任意): (英) Selective serotonin reuptake inhibitors (SSRIs) are widely used for the treatment of depressive mood disorders and well known to inhibit the reuptake of neurotransmitter serotonin into nerve terminals. Thus, it seems conceivable that these drugs may induce the outflow of serotonin from the synapse as a consequence of inhibiting the reuptake, resulting in the stimulation of glial cells surrounding nerve terminals. On this hypothesis, the effect of serotonin on steroid 5alpha-reductase type 1 (5alpha-R) gene expression in rat C6 glioma cells was examined as one of the in vitro model experiments for investigating the indirect influence of SSRIs on glial cells. Serotonin elevated 5alpha-R mRNA and protein levels through the stimulation of serotonin 5-HT2A receptors, and also elevated Egr-1 mRNA and protein levels prior to 5alpha-R gene expression in the glioma cells. Furthermore, serotonin failed to significantly increase 5alpha-R mRNA levels in the cells preloaded with the antisense oligodeoxynucleotide targeted on Egr-1 gene. These results indicate that serotonin may stimulate 5alpha-R gene expression via transcription factor Egr-1 in glial cells, thus suggesting that serotonin flowing out of the serotonergic synapse may be implicated in SSRI-induced changes in neurosteroid metabolism in brain.  (日)    [継承]
キーワード (推奨): 1. (英) 3-Oxo-5-alpha-Steroid 4-Dehydrogenase (日) (読) [継承]
2. (英) Animals (日) (読) [継承]
3. (英) Blotting, Northern (日) (読) [継承]
4. (英) Blotting, Western (日) (読) [継承]
5. (英) Cell Line, Tumor (日) (読) [継承]
6. (英) Dose-Response Relationship, Drug (日) (読) [継承]
7. (英) Early Growth Response Protein 1 (日) (読) [継承]
8. (英) Gene Expression (日) (読) [継承]
9. (英) Gene Expression Regulation (日) (読) [継承]
10. (英) Glioma (日) (読) [継承]
11. (英) Naphthalenes (日) (読) [継承]
12. (英) Oligoribonucleotides, Antisense (日) (読) [継承]
13. (英) Oxepins (日) (読) [継承]
14. (英) RNA, Messenger (日) (読) [継承]
15. (英) Rats (日) (読) [継承]
16. (英) Receptor, Serotonin, 5-HT2A (日) (読) [継承]
17. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
18. (英) Serotonin (日) (読) [継承]
19. (英) Time Factors (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Brain Research. Molecular Brain Research (Elsevier)
(pISSN: 0169-328X)

ISSN (任意): 0169-328X
ISSN: 0169-328X (pISSN: 0169-328X)
Title: Brain research. Molecular brain research
Title(ISO): Brain Res. Mol. Brain Res.
Publisher: Elsevier BV
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 139 [継承]
(必須): 2 [継承]
(必須): 193 200 [継承]
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年月日 (必須): 西暦 2005年 10月 3日 (平成 17年 10月 3日) [継承]
URL (任意):
DOI (任意): 10.1016/j.molbrainres.2005.05.013    (→Scopusで検索) [継承]
PMID (任意): 15936112    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Pharmacology, Tokushima University School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. km@basic.med.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Kyoji Morita, Hideki Arimochi and Song Her : Serotonergic 5-HT2A receptor stimulation induces steroid 5a-reductase gene expression in rat C6 glioma cells via transcription factor Egr-1, Brain Research. Molecular Brain Research, Vol.139, No.2, 193-200, 2005.
欧文冊子 ● Kyoji Morita, Hideki Arimochi and Song Her : Serotonergic 5-HT2A receptor stimulation induces steroid 5a-reductase gene expression in rat C6 glioma cells via transcription factor Egr-1, Brain Research. Molecular Brain Research, Vol.139, No.2, 193-200, 2005.

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