『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Nakashiro Ko-ichi (日) (読)
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貢献度 (任意):
学籍番号 (推奨):
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2. (英) Begum Nasima Mila (日) (読)
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3.内田 大亮
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4. (英) Kawamata Hitoshi (日) (読)
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5. (英) Shintani Satoru (日) (読)
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6.佐藤 光信
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7. (英) Hamakawa Hiroyuki (日) (読)
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題名 (必須): (英) Thiazolidinediones inhibit cell growth of human oral squamous cell carcinoma in vitro independent of peroxisome proliferator-activated receptor gamma  (日)    [継承]
副題 (任意):
要約 (任意): (英) Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. Recently, we have demonstrated that PPARgamma is expressed in human salivary gland tumors and its ligands inhibit the growth of cultured salivary gland cancer cells. However, expression and function of PPARgamma in normal and neoplastic human oral squamous epithelium remains unclear. In the present study, we examined PPARgamma expression in human oral squamous cell carcinoma (OSCC) and tested its ligands for any antitumor effect. PPARgamma mRNA was detected by RT-PCR in some OSCC tissues and cultured cells, but the PPARgamma protein showed neither expression nor ligand-induced transcriptional activity. Despite loss of PPARgamma function, synthetic PPARgamma ligands caused significant dose-dependent inhibition of cancer cell growth. These results suggest that PPARgamma function is inactivated in OSCC cells and the anti-proliferative effect of its synthetic ligands is independent of PPARgamma.  (日)    [継承]
キーワード (推奨): 1. (英) oral squamous cell carcinoma (日) (読) [継承]
2. (英) PPAR gamma (日) (読) [継承]
3. (英) troglitazone (日) (読) [継承]
4. (英) pioglitazone (日) (読) [継承]
5. (英) HUMAN BREAST-CANCER (日) (読) [継承]
6. (英) PPAR-GAMMA (日) (読) [継承]
7. (英) TERMINAL DIFFERENTIATION (日) (読) [継承]
8. (英) DOWN-REGULATION (日) (読) [継承]
9.レチノイン酸 (retinoic acid) [継承]
10. (英) COLON-CANCER (日) (読) [継承]
11. (英) LIGANDS (日) (読) [継承]
12. (英) EXPRESSION (日) (読) [継承]
13.アポトーシス (apoptosis) [継承]
14. (英) VIVO (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Oral Oncology (European Association of Oral Medicine/International Association of Oral Pathologists/International Academy of Oral Oncology)
(pISSN: 1368-8375, eISSN: 1879-0593)

ISSN (任意): 1368-8375
ISSN: 1368-8375 (pISSN: 1368-8375, eISSN: 1879-0593)
Title: Oral oncology
Title(ISO): Oral Oncol.
Publisher: Elsevier Ltd.
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 39 [継承]
(必須): 8 [継承]
(必須): 855 861 [継承]
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年月日 (必須): 西暦 2003年 12月 初日 (平成 15年 12月 初日) [継承]
URL (任意):
DOI (任意): 10.1016/S1368-8375(03)00108-8    (→Scopusで検索) [継承]
PMID (任意): 13679209    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): 000186680500012 [継承]
Scopus (任意): 2-s2.0-1642293386 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Department of Oral and Maxillofacial Surgery, Ehime University School of Medicine, 454 Shitsukawa, Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan. nakako@m.ehime-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Ko-ichi Nakashiro, Mila Nasima Begum, Daisuke Uchida, Hitoshi Kawamata, Satoru Shintani, Mitsunobu Sato and Hiroyuki Hamakawa : Thiazolidinediones inhibit cell growth of human oral squamous cell carcinoma in vitro independent of peroxisome proliferator-activated receptor gamma, Oral Oncology, Vol.39, No.8, 855-861, 2003.
欧文冊子 ● Ko-ichi Nakashiro, Mila Nasima Begum, Daisuke Uchida, Hitoshi Kawamata, Satoru Shintani, Mitsunobu Sato and Hiroyuki Hamakawa : Thiazolidinediones inhibit cell growth of human oral squamous cell carcinoma in vitro independent of peroxisome proliferator-activated receptor gamma, Oral Oncology, Vol.39, No.8, 855-861, 2003.

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