『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
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組織 (推奨):
著者 (必須): 1. (英) Begum Nasima Mila (日) (読)
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2. (英) Nakashiro Ko-ichi (日) (読)
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3. (英) Kawamata Hitoshi (日) (読)
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4.内田 大亮
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5. (英) Shintani Satoru (日) (読)
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6. (英) Ikawa Yoji (日) (読)
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7.佐藤 光信
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8. (英) Hamakawa Hiroyuki (日) (読)
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題名 (必須): (英) Expression of peroxisome proliferator-activated receptor _ and the growth inhibitory effect of its synthetic ligands in human salivary gland cancer cell lines  (日)    [継承]
副題 (任意):
要約 (任意): (英) Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. It is expressed in several tissue types, including adipose tissue in which it stimulates adipogenesis. Recent studies have demonstrated that PPARgamma ligands induce cellular differentiation and inhibit cell growth in carcinomas of various organs including the breast, prostate, lung, colon, stomach, bladder, and pancreas. However, whether PPARgamma is expressed in human salivary gland tumors and its function in this tissue is unknown. In the present study, we examined PPARgamma gene expression in human salivary gland cancer cells and tested its ligands for any antitumor effect. PPARgamma mRNA was detected by RT-PCR in both benign and malignant salivary gland tumor tissues. The effect of PPARgamma on cell growth was investigated using four human salivary gland cancer cell lines; HSG, AZA3, HSY and TYS, which were confirmed to express PPARgamma1 mRNA and protein. Retinoid X receptor alpha protein, which forms heterodimers with PPARgamma, was also detected in all the cells tested. Data obtained by luciferase assay indicated that the intrinsic PPARgamma protein was activated by the synthetic ligands, troglitazone and pioglitazone, but not by the natural ligand, 15-deoxy-delta12, 14-prostaglandin J2. The synthetic PPARgamma ligands, particularly troglitazone, caused significant dose-dependent inhibition of cancer cell growth. Furthermore, the overexpression of PPARgamma1 or PPARgamma2 in cancer cells also reduced significantly their growth rate. These results suggest that PPARgamma and its synthetic ligands suppress the growth of human salivary gland cancer cells and it may be a useful molecular target for cancer treatment.  (日)    [継承]
キーワード (推奨): 1. (英) PPAR gamma (日) (読) [継承]
2. (英) salivary gland cancer (日) (読) [継承]
3. (英) HUMAN BREAST-CANCER (日) (読) [継承]
4. (英) PPAR-GAMMA (日) (読) [継承]
5. (英) IN-VITRO (日) (読) [継承]
6. (英) TERMINAL DIFFERENTIATION (日) (読) [継承]
7.レチノイン酸 (retinoic acid) [継承]
8. (英) COLON-CANCER (日) (読) [継承]
9.遺伝子 (gene) [継承]
10. (英) TROGLITAZONE (日) (読) [継承]
11. (英) MUTATIONS (日) (読) [継承]
12.アポトーシス (apoptosis) [継承]
発行所 (推奨):
誌名 (必須): International Journal of Oncology (International Center for Cancer Research)
(pISSN: 1019-6439, eISSN: 1791-2423)

ISSN (任意): 1019-6439
ISSN: 1019-6439 (pISSN: 1019-6439, eISSN: 1791-2423)
Title: International journal of oncology
Title(ISO): Int. J. Oncol.
Publisher: Spandidos Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 20 [継承]
(必須): 3 [継承]
(必須): 599 605 [継承]
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年月日 (必須): 西暦 2002年 3月 初日 (平成 14年 3月 初日) [継承]
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PMID (任意): 11836575    (→Scopusで検索) [継承]
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WOS (任意): 000173883400023 [継承]
Scopus (任意): 2-s2.0-0036511152 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, Tokushima 770-8504, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Mila Nasima Begum, Ko-ichi Nakashiro, Hitoshi Kawamata, Daisuke Uchida, Satoru Shintani, Yoji Ikawa, Mitsunobu Sato and Hiroyuki Hamakawa : Expression of peroxisome proliferator-activated receptor _ and the growth inhibitory effect of its synthetic ligands in human salivary gland cancer cell lines, International Journal of Oncology, Vol.20, No.3, 599-605, 2002.
欧文冊子 ● Mila Nasima Begum, Ko-ichi Nakashiro, Hitoshi Kawamata, Daisuke Uchida, Satoru Shintani, Yoji Ikawa, Mitsunobu Sato and Hiroyuki Hamakawa : Expression of peroxisome proliferator-activated receptor _ and the growth inhibitory effect of its synthetic ligands in human salivary gland cancer cell lines, International Journal of Oncology, Vol.20, No.3, 599-605, 2002.

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