『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=124342)

EID=124342EID:124342, Map:0, LastModified:2016年9月9日(金) 12:01:43, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[学科長]/[徳島大学.歯学部.歯学科]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kawamata Hitoshi (日) 川又 均 (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2. (英) Nakashiro Ko-ichi (日) 中城 公一 (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3.内田 大亮
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4. (英) Hino Satoshi (日) 日野 聡史 (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.原田 耕志
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.吉田 秀夫
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.佐藤 光信
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Possible contribution of active MMP2 to lymph-node metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell lines  (日)    [継承]
副題 (任意):
要約 (任意): (英) We have established human oral-squamous-cancer cell lines, BHY and HN, derived from non-metastatic cancer and metastatic cancer respectively. We examined the expression of matrix-degrading enzymes and their inhibitors in these cell lines. Both cell lines expressed pro-matrix metalloproteinase (MMP)1, proMMP2, proMMP9, membrane-type MMP and urokinase-type plasminogen activator. In addition to these enzymes, BHY cells secreted proMMP7 and procathepsin L, while HN cells secreted a large amount of active MMP2. BHY cells secreted a tissue inhibitor of matrix metalloproteinase, TIMP2, but only a trace level of TIMP1. Contrary to BHY cells, HN cells secreted TIMP1, but only a trace level of TIMP2. When we inoculated these cells into the masseter muscle of nude mice, both types of cell formed solid tumors, whose microscopic appearance was identical to that of the original tumors. BHY tumors were highly differentiated squamous-cell carcinomas, and invasive to the masseter muscle and the mandibular bone. Despite their local aggressiveness, BHY tumors did not metastasize to any distant organs. HN tumors were poorly differentiated squamous-cell carcinomas, weakly invasive to the muscle, but not to the mandibular bone. However, HN tumors frequently metastasized to cervical lymph nodes. These results suggest that the net activity of MMP2 (active MMP2/TIMP2) and cathepsin L secreted from cancer cells may contribute respectively to lymph-node metastasis and to bone invasion by oral cancer cells.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Carcinoma, Squamous Cell (日) (読) [継承]
3. (英) Cathepsin L (日) (読) [継承]
4. (英) Cathepsins (日) (読) [継承]
5. (英) Collagenases (日) (読) [継承]
6. (英) Cysteine Endopeptidases (日) (読) [継承]
7. (英) Endopeptidases (日) (読) [継承]
8. (英) Gelatinases (日) (読) [継承]
9. (英) Glycoproteins (日) (読) [継承]
10. (英) Humans (日) (読) [継承]
11. (英) Matrix Metalloproteinase 1 (日) (読) [継承]
12. (英) Matrix Metalloproteinase 2 (日) (読) [継承]
13. (英) Metalloendopeptidases (日) (読) [継承]
14. (英) Mice (日) (読) [継承]
15. (英) Mice, Nude (日) (読) [継承]
16. (英) Mouth Neoplasms (日) (読) [継承]
17. (英) Neoplasm Proteins (日) (読) [継承]
18. (英) Proteins (日) (読) [継承]
19. (英) RNA, Messenger (日) (読) [継承]
20. (英) Tissue Inhibitor of Metalloproteinase-2 (日) (読) [継承]
21. (英) Tissue Inhibitor of Metalloproteinases (日) (読) [継承]
22. (英) Tumor Cells, Cultured (日) (読) [継承]
発行所 (推奨):
誌名 (必須): International Journal of Cancer ([国際対ガン連合])
(pISSN: 0020-7136, eISSN: 1097-0215)

ISSN (任意): 0020-7136
ISSN: 0020-7136 (pISSN: 0020-7136, eISSN: 1097-0215)
Title: International journal of cancer
Title(ISO): Int. J. Cancer
Supplier: Union for International Cancer Control
Publisher: Wiley
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 70 [継承]
(必須): 1 [継承]
(必須): 120 127 [継承]
都市 (任意):
年月日 (必須): 西暦 1997年 1月 6日 (平成 9年 1月 6日) [継承]
URL (任意):
DOI (任意): 10.1002/(SICI)1097-0215(19970106)70:1<120::AID-IJC18>3.0.CO;2-P    (→Scopusで検索) [継承]
PMID (任意): 8985100    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意): A1997WA88700018 [継承]
Scopus (任意): 2-s2.0-0031019147 [継承]
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Second Department of Oral and Maxillofacial Surgery, Tokushima University School of Dentistry, Japan. kawamata@dent.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Hitoshi Kawamata, Ko-ichi Nakashiro, Daisuke Uchida, Satoshi Hino, Koji Harada, Hideo Yoshida and Mitsunobu Sato : Possible contribution of active MMP2 to lymph-node metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell lines, International Journal of Cancer, Vol.70, No.1, 120-127, 1997.
欧文冊子 ● Hitoshi Kawamata, Ko-ichi Nakashiro, Daisuke Uchida, Satoshi Hino, Koji Harada, Hideo Yoshida and Mitsunobu Sato : Possible contribution of active MMP2 to lymph-node metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell lines, International Journal of Cancer, Vol.70, No.1, 120-127, 1997.

関連情報

Number of session users = 0, LA = 3.24, Max(EID) = 360707, Max(EOID) = 966167.