『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=122444EID:122444, Map:0, LastModified:2015年1月15日(木) 13:51:58, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[宇都 義浩], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.京都大学 [継承]
著者 (必須): 1. (英) Masunaga Shin-ichiro (日) (読)
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2.永澤 秀子 (岐阜薬科大学/->個人[紺世 秀子])
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3.宇都 義浩 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.応用生物資源学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
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[継承]
4.堀 均
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[継承]
5. (英) Ohnishi K. (日) (読)
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[継承]
6. (英) Takahashi A. (日) (読)
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[継承]
7. (英) Ohnishi T. (日) (読)
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[継承]
8. (英) Suzuki M. (日) (読)
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[継承]
9. (英) Nagata K. (日) (読)
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[継承]
10. (英) Kinashi Y. (日) (読)
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[継承]
11. (英) Ono K. (日) (読)
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[継承]
題名 (必須): (英) Combination of the antivascular agent ZD6126 with hypoxic cytotoxin treatment, with reference to the effect on quiescent tumor cells and the dependency on p53 status of tumor cells  (日)    [継承]
副題 (任意):
要約 (任意): (英) Human head and neck squamous cell carcinoma cells transfected with mutant TP53 (SAS/mp53) or with neo vector as a control (SAS/neo) were inoculated subcutaneously into both the hind legs of Balb/cA nude mice. Mice bearing the tumors received 5-bromo-2'-deoxyuridine (BrdU) continuously to label all proliferating (P) cells in the tumors. The mice then received a hypoxic cytotoxin, tirapazamine (TPZ) or TX-402, with or without a vascular targeting agent (VTA), ZD6126. Another group of mice given ZD6126 received a series of test doses of gamma-rays while alive or after tumor clamping to obtain hypoxic fractions (HFs) in the tumors. After each treatment, the tumor cells were isolated and incubated with a cytokinesis blocker (cytochalasin-B), and the micronucleus (MN) frequency in cells without BrdU labeling [quiescent (Q) cells] was determined using immunofluorescence staining for BrdU. The MN frequency in total (P+Q) tumor cells was determined from the tumors that were not pretreated with BrdU. Both hypoxic cytotoxins showed significantly greater toxicity toward SAS/mp53 and Q than SAS/neo and total tumor cells, respectively. The sensitivity to TX-402 was significantly higher than that to TPZ in both total and Q tumor cells of both tumors. The significant enhancive effect by ZD6126 combined with each hypoxic cytotoxin was similar irrespective of p53 status, and slightly greater for total than Q cells probably because of a more marked increase in the size of the HFs in total than Q cells on the use of ZD6126 in both tumors, resulting in a reduction of the difference in the sensitivity to the hypoxic cytotoxin between total and Q cells. In the treatment of conventional cancer therapy-resistant Q tumor cells or p53-mutated tumor cells, the use of hypoxic cytotoxin was very promising either alone or when VTA was co-administered. TX-402 might be more promising than TPZ, although further study of the toxicity to normal tissue is needed.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antineoplastic Combined Chemotherapy Protocols (日) (読) [継承]
3. (英) Carcinoma, Squamous Cell (日) (読) [継承]
4. (英) Cell Hypoxia (日) (読) [継承]
5. (英) Cell Line, Tumor (日) (読) [継承]
6. (英) Cell Proliferation (日) (読) [継承]
7. (英) Cell Survival (日) (読) [継承]
8. (英) Combined Modality Therapy (日) (読) [継承]
9. (英) Cyclic N-Oxides (日) (読) [継承]
10. (英) Gamma Rays (日) (読) [継承]
11. (英) Head and Neck Neoplasms (日) (読) [継承]
12. (英) Humans (日) (読) [継承]
13. (英) Mice (日) (読) [継承]
14. (英) Mice, Inbred BALB C (日) (読) [継承]
15. (英) Mice, Nude (日) (読) [継承]
16. (英) Micronucleus Tests (日) (読) [継承]
17. (英) Mutation (日) (読) [継承]
18. (英) Organophosphorus Compounds (日) (読) [継承]
19. (英) Quinoxalines (日) (読) [継承]
20. (英) Radiotherapy (日) (読) [継承]
21. (英) Triazines (日) (読) [継承]
22. (英) Tumor Suppressor Protein p53 (日) (読) [継承]
23. (英) Xenograft Model Antitumor Assays (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Oncology Reports (Ethnikon Hidryma Ereunōn (Greece))
(pISSN: 1021-335X, eISSN: 1791-2431)

ISSN (任意): 1021-335X
ISSN: 1021-335X (pISSN: 1021-335X, eISSN: 1791-2431)
Title: Oncology reports
Title(ISO): Oncol. Rep.
Publisher: Spandidos Publications
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 14 [継承]
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(必須): 394 400 [継承]
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年月日 (必須): 西暦 2005年 7月 初日 (平成 17年 7月 初日) [継承]
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PMID (任意): 16012721    (→Scopusで検索) [継承]
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WOS (任意): 000230539600016 [継承]
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備考 (任意): 1.(英) Article.Affiliation: Radiation Oncology Research Laboratory, Research Reactor Institute, Kyoto University, 2-1010, Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan. smasuna@rri.kyoto-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Shin-ichiro Masunaga, Hideko Nagasawa, Yoshihiro Uto, Hitoshi Hori, K. Ohnishi, A. Takahashi, T. Ohnishi, M. Suzuki, K. Nagata, Y. Kinashi and K. Ono : Combination of the antivascular agent ZD6126 with hypoxic cytotoxin treatment, with reference to the effect on quiescent tumor cells and the dependency on p53 status of tumor cells, Oncology Reports, Vol.14, No.2, 394-400, 2005.
欧文冊子 ● Shin-ichiro Masunaga, Hideko Nagasawa, Yoshihiro Uto, Hitoshi Hori, K. Ohnishi, A. Takahashi, T. Ohnishi, M. Suzuki, K. Nagata, Y. Kinashi and K. Ono : Combination of the antivascular agent ZD6126 with hypoxic cytotoxin treatment, with reference to the effect on quiescent tumor cells and the dependency on p53 status of tumor cells, Oncology Reports, Vol.14, No.2, 394-400, 2005.

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