| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.発達予防医歯学部門.病態予防医学講座 (2004年4月1日〜)
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| ○著者 (必須): | 1. | 池原 敏孝 ([徳島文理大学])
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| 2. | 山口 久雄 ([徳島文理大学])
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| 3. | 細川 敬子
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| 4. | 芳地 一
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| 5. | 朴 基豪 (University of Medicine and Dentistry of New Jersey)
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| 6. | 水口 和生
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| 7. | (英) Kashimoto Hideki (日) 樫本 英樹 (読) かしもとひでき
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| 8. | 北村 光夫 ([徳島大学.技術支援部])
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| 9. | 木内 陽介
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| 10. | 吉﨑 和男
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| 11. | 宮本 博司 ([徳島文理大学])
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| ○題名 (必須): | □ | (英) Effects of a time-varying strong magnetic field on transient increase in Ca2+ release induced by cytosolic Ca2+ in cultured pheochromocytoma cells (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Exposure of pheochromocytoma (PC 12) cells to a time-varying 1.51 T magnetic field inhibited an increase in the intracellular Ca2+ concentration ([Ca2+]i) induced by addition of caffeine to Ca(2+)-free medium. This inhibition occurred after a 15-min exposure and was maintained for at least 2 h. [Ca2+]i sharply increased in cells loaded with cyclic ADP-ribose, and 2-h exposure significantly suppressed the increase. Addition of ATP induced a transient increase in intracellular Ca2+ release mediated by IP3 receptor, and this increase was strongly inhibited by the exposure. Results indicated that the magnetic field exposure strongly inhibited Ca2+ release mediated by both IP3 and ryanodine receptors in PC 12 cells. However, thapsigargin-induced Ca2+ influx (capacitative Ca2+ entry) across the cell membrane was unaffected. The ATP content was maintained at the normal level during the 2-h exposure, suggesting that ATP hydrolysis was unchanged. Therefore, Mg2+ which is known to be released by ATP hydrolysis and inhibit intracellular Ca2+ release may not relate the exposure-caused inhibition. Eddy currents induced in culture medium appear to change cell membrane properties and indirectly inhibit Ca2+ release from endoplasmic reticulum and other Ca2+ stores in PC 12 cells. (日)
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| ○キーワード (推奨): | 1. | (英) ryanodine receptor (日) (読)
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| 2. | (英) caffeine (日) (読)
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| 3. | (英) cyclic ADP-ribose (日) (読)
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| 4. | (英) time-varying magnetic field (日) (読)
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| 5. | (英) eddy current (日) (読)
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| ○発行所 (推奨): | □ | Elsevier Science
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| ○誌名 (必須): | □ | Biochimica et Biophysica Acta (BBA) - General Subjects ([Elsevier Science])
(pISSN: 0304-4165)
| ○ISSN (任意): | □ | 0304-4165
ISSN: 0304-4165
(pISSN: 0304-4165, eISSN: 1872-8006) Title: Biochimica et biophysica acta. General subjectsTitle(ISO): Biochim Biophys Acta Gen SubjPublisher: Elsevier BV (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 1724
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| ○号 (必須): | □ | 1-2
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| ○頁 (必須): | □ | 8 16
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2005年 4月 2日 (平成 17年 4月 2日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/j.bbagen.2005.03.008 (→Scopusで検索)
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| ○PMID (任意): | □ | 15890451 (→Scopusで検索)
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| ○NAID (任意): |
| ○WOS (任意): | □ | 000230182400002
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| ○Scopus (任意): | □ | 2-s2.0-20444422530
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Physiology, Pathophysiological Preventive Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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