| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座 (2004年4月1日〜2015年3月31日)
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| ○著者 (必須): | 1. | 姚 陳娟 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔生理学])
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| 2. | 李 雪飛
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| 3. | (英) Kwartarini Murdiastuti (日) (読)
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| 4. | 小杉 知里
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| 5. | 赤松 徹也 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命コース])
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| 6. | 金森 憲雄
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| 7. | 細井 和雄
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| ○題名 (必須): | □ | (英) Lipopolysaccharide-induced elevation and secretion of Interleukin-1b in the submandibular gland of male mice (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The intraperitoneal injection of lipopolysaccharide (LPS) (400 microg/kg body weight) induced the expression of mRNAs of inflammatory cytokines such as interleukin (IL)-1beta, IL-6 and tumour necrosis factor (TNF)-alpha in the submandibular gland (SMG) of C3H/HeN mice but not that of C3H/HeJ mice, a mutant strain for Toll-like receptor-4 (TLR-4(-) mutant). The mRNA levels of these cytokines in the SMG of the wild-type mice increased as early as 3 hr after injection, peaked at 3-6 hr, and had decreased again by 24 hr. In this study, we particularly focused on IL-1beta, and induction by this endotoxin was investigated in detail. Denervation of the superior cervical trunk and chorda tympani nerve did not diminish the LPS-induced elevation of IL-1beta mRNA in the SMG, indicating the irrelevance of the central nervous system in this induction. TLR-4 mRNA and protein were shown to be strongly expressed in the SMG, suggesting the direct action of LPS on this gland. IL-1beta proteins were localized in the secretory granules of granular convoluted tubular (GCT) cells, and their molecular weights in the gland were 17.5 and 20 kDa. IL-1beta of the same size appeared in the saliva 6 hr after LPS injection in C3H/HeN but not in C3H/HeJ mice. The present study thus suggests that IL-1beta, an inflammation cytokine, is induced and secreted into the saliva in response to endotoxin injected intraperitoneally. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Blotting, Western (日) (読)
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| 3. | (英) Cytokines (日) (読)
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| 4. | (英) Gene Expression Regulation (日) (読)
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| 5. | (英) Injections, Intraperitoneal (日) (読)
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| 6. | (英) Interleukin-1 (日) (読)
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| 7. | (英) Lipopolysaccharides (日) (読)
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| 8. | (英) Male (日) (読)
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| 9. | (英) Mice (日) (読)
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| 10. | (英) Mice, Inbred C3H (日) (読)
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| 11. | (英) RNA, Messenger (日) (読)
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| 12. | (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読)
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| 13. | (英) Saliva (日) (読)
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| 14. | (英) Submandibular Gland (日) (読)
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| ○発行所 (推奨): | □ | Blackwell Publishing Ltd
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| ○誌名 (必須): | □ | Immunology (British Society for Immunology)
(pISSN: 0019-2805, eISSN: 1365-2567)
| ○ISSN (任意): | □ | 0019-2805
ISSN: 0019-2805
(pISSN: 0019-2805, eISSN: 1365-2567) Title: ImmunologyTitle(ISO): ImmunologySupplier: British Society for ImmunologyPublisher: Wiley Publishing (NLM Catalog)
(Wiley)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 116
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 213 222
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2005年 10月 初日 (平成 17年 10月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1111/j.1365-2567.2005.02212.x (→Scopusで検索)
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| ○PMID (任意): | □ | 16162270 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Molecular Oral Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima-shi, Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) OtherID: PMC1817826 (日)
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