『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
ID: Pass:

登録内容 (EID=121653)

EID=121653EID:121653, Map:0, LastModified:2012年9月3日(月) 17:04:45, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[細井 和雄], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨): Peer Review [継承]
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座 (2004年4月1日〜2015年3月31日) [継承]
著者 (必須): 1.姚 陳娟 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子生理学])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
2.李 雪飛
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
3. (英) Kwartarini Murdiastuti (日) (読)
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
4.小杉 知里
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
5.赤松 徹也 ([徳島大学.大学院社会産業理工学研究部.生物資源産業学域.応用生命系.生体分子機能学分野]/[徳島大学.生物資源産業学部.生物資源産業学科.応用生命講座])
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
6.金森 憲雄
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
7.細井 和雄
役割 (任意):
貢献度 (任意):
学籍番号 (推奨):
[継承]
題名 (必須): (英) Lipopolysaccharide-induced elevation and secretion of Interleukin-1b in the submandibular gland of male mice  (日)    [継承]
副題 (任意):
要約 (任意): (英) The intraperitoneal injection of lipopolysaccharide (LPS) (400 microg/kg body weight) induced the expression of mRNAs of inflammatory cytokines such as interleukin (IL)-1beta, IL-6 and tumour necrosis factor (TNF)-alpha in the submandibular gland (SMG) of C3H/HeN mice but not that of C3H/HeJ mice, a mutant strain for Toll-like receptor-4 (TLR-4(-) mutant). The mRNA levels of these cytokines in the SMG of the wild-type mice increased as early as 3 hr after injection, peaked at 3-6 hr, and had decreased again by 24 hr. In this study, we particularly focused on IL-1beta, and induction by this endotoxin was investigated in detail. Denervation of the superior cervical trunk and chorda tympani nerve did not diminish the LPS-induced elevation of IL-1beta mRNA in the SMG, indicating the irrelevance of the central nervous system in this induction. TLR-4 mRNA and protein were shown to be strongly expressed in the SMG, suggesting the direct action of LPS on this gland. IL-1beta proteins were localized in the secretory granules of granular convoluted tubular (GCT) cells, and their molecular weights in the gland were 17.5 and 20 kDa. IL-1beta of the same size appeared in the saliva 6 hr after LPS injection in C3H/HeN but not in C3H/HeJ mice. The present study thus suggests that IL-1beta, an inflammation cytokine, is induced and secreted into the saliva in response to endotoxin injected intraperitoneally.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Blotting, Western (日) (読) [継承]
3. (英) Cytokines (日) (読) [継承]
4. (英) Gene Expression Regulation (日) (読) [継承]
5. (英) Injections, Intraperitoneal (日) (読) [継承]
6. (英) Interleukin-1 (日) (読) [継承]
7. (英) Lipopolysaccharides (日) (読) [継承]
8. (英) Male (日) (読) [継承]
9. (英) Mice (日) (読) [継承]
10. (英) Mice, Inbred C3H (日) (読) [継承]
11. (英) RNA, Messenger (日) (読) [継承]
12. (英) Reverse Transcriptase Polymerase Chain Reaction (日) (読) [継承]
13. (英) Saliva (日) (読) [継承]
14. (英) Submandibular Gland (日) (読) [継承]
発行所 (推奨): Blackwell Publishing Ltd [継承]
誌名 (必須): Immunology (British Society for Immunology)
(pISSN: 0019-2805, eISSN: 1365-2567)

ISSN (任意): 0019-2805
ISSN: 0019-2805 (pISSN: 0019-2805, eISSN: 1365-2567)
Title: Immunology
Title(ISO): Immunology
Supplier: British Society for Immunology
Publisher: Wiley Publishing
 (NLM Catalog  (Wiley  (Scopus  (CrossRef (Scopus information is found. [need login])
[継承]
[継承]
(必須): 116 [継承]
(必須): 2 [継承]
(必須): 213 222 [継承]
都市 (任意):
年月日 (必須): 西暦 2005年 10月 初日 (平成 17年 10月 初日) [継承]
URL (任意):
DOI (任意): 10.1111/j.1365-2567.2005.02212.x    (→Scopusで検索) [継承]
PMID (任意): 16162270    (→Scopusで検索) [継承]
NAID (任意):
WOS (任意):
Scopus (任意):
評価値 (任意):
被引用数 (任意):
指導教員 (推奨):
備考 (任意): 1.(英) Article.Affiliation: Department of Molecular Oral Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima-shi, Tokushima, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) OtherID: PMC1817826  (日)    [継承]

標準的な表示

和文冊子 ● Chenjuan Yao, Xuefei Li, Murdiastuti Kwartarini, Chisato Kosugi, Tetsuya Akamatsu, Norio Kanamori and Kazuo Hosoi : Lipopolysaccharide-induced elevation and secretion of Interleukin-1b in the submandibular gland of male mice, Immunology, Vol.116, No.2, 213-222, 2005.
欧文冊子 ● Chenjuan Yao, Xuefei Li, Murdiastuti Kwartarini, Chisato Kosugi, Tetsuya Akamatsu, Norio Kanamori and Kazuo Hosoi : Lipopolysaccharide-induced elevation and secretion of Interleukin-1b in the submandibular gland of male mice, Immunology, Vol.116, No.2, 213-222, 2005.

関連情報

Number of session users = 0, LA = 1.30, Max(EID) = 373299, Max(EOID) = 998707.