| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 分子酵素学研究センター (〜2007年3月31日/->組織[疾患酵素学研究センター])
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| ○著者 (必須): | 1. | 黒田 範行
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) Mitani Tasuku (日) (読)
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| 3. | (英) Takeda Naoki (日) (読)
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| 4. | 石丸 直澄 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
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| 5. | 新垣 理恵子 ([徳島大学.大学院医歯薬学研究部.歯学域.口腔科学部門.基礎歯学系.口腔分子病態学])
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| 6. | 林 良夫
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| 7. | 坂東 良美 ([徳島大学.病院.中央診療施設等.病理部])
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| 8. | 泉 啓介
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| 9. | (英) Takahashi Takeshi (日) (読)
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| 10. | (英) Nomura Takashi (日) (読)
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| 11. | (英) Sakaguchi Shimon (日) (読)
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| 12. | 上野 智雄
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| 13. | 高浜 洋介
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| [継承] |
| 14. | 内田 大亮
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| ○貢献度 (任意): |
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| [継承] |
| 15. | (英) Sun Shijie (日) (読)
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| [継承] |
| 16. | (英) Kajiura Fumiko (日) (読)
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| 17. | 毛利 安宏
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| 18. | (英) Han Hongwei (日) (読)
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| 19. | 松島 明美
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| [継承] |
| 20. | (英) Yamada Gen (日) (読)
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| 21. | 松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| ○題名 (必須): | □ | (英) Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Autoimmune regulator (AIRE) gene mutation is responsible for the development of organ-specific autoimmune disease with monogenic autosomal recessive inheritance. Although Aire has been considered to regulate the elimination of autoreactive T cells through transcriptional control of tissue-specific Ags in thymic epithelial cells, other mechanisms of AIRE-dependent tolerance remain to be investigated. We have established Aire-deficient mice and examined the mechanisms underlying the breakdown of self-tolerance. The production and/or function of immunoregulatory T cells were retained in the Aire-deficient mice. The mice developed Sjogren's syndrome-like pathologic changes in the exocrine organs, and this was associated with autoimmunity against a ubiquitous protein, alpha-fodrin. Remarkably, transcriptional expression of alpha-fodrin was retained in the Aire-deficient thymus. These results suggest that Aire regulates the survival of autoreactive T cells beyond transcriptional control of self-protein expression in the thymus, at least against this ubiquitous protein. Rather, Aire may regulate the processing and/or presentation of self-proteins so that the maturing T cells can recognize the self-Ags in a form capable of efficiently triggering autoreactive T cells. With the use of inbred Aire-deficient mouse strains, we also demonstrate the presence of some additional factor(s) that determine the target-organ specificity of the autoimmune disease caused by Aire deficiency. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Autoantibodies (日) (読)
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| 3. | (英) Autoantigens (日) (読)
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| 4. | (英) Carrier Proteins (日) (読)
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| 5. | (英) Exocrine Glands (日) (読)
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| 6. | (英) Female (日) (読)
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| 7. | (英) Male (日) (読)
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| 8. | (英) Mice (日) (読)
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| 9. | (英) Mice, Inbred BALB C (日) (読)
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| 10. | (英) Mice, Inbred C57BL (日) (読)
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| 11. | (英) Mice, Inbred ICR (日) (読)
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| 12. | (英) Mice, Knockout (日) (読)
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| 13. | (英) Mice, Nude (日) (読)
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| 14. | (英) Microfilament Proteins (日) (読)
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| 15. | (英) Organ Specificity (日) (読)
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| 16. | (英) Polyendocrinopathies, Autoimmune (日) (読)
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| 17. | (英) Self Tolerance (日) (読)
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| 18. | (英) Sjogren's Syndrome (日) (読)
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| 19. | (英) Species Specificity (日) (読)
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| 20. | (英) Stromal Cells (日) (読)
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| 21. | (英) T-Lymphocytes, Regulatory (日) (読)
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| 22. | (英) Thymus Gland (日) (読)
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| 23. | (英) Transcription Factors (日) (読)
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| ○発行所 (推奨): | □ | The American Association of Immunologists
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| ○誌名 (必須): | □ | The Journal of Immunology ([The American Association of Immunologists])
(pISSN: 0022-1767, eISSN: 1550-6606)
| ○ISSN (任意): | □ | 0022-1767
ISSN: 0022-1767
(pISSN: 0022-1767, eISSN: 1550-6606) Title: Journal of immunology (Baltimore, Md. : 1950)Title(ISO): J. Immunol.Publisher: American Association of Immunologists (NLM Catalog)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 174
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 1862 1870
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2005年 2月 15日 (平成 17年 2月 15日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.3410/f.1024264.287833 (→Scopusで検索)
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| ○PMID (任意): | □ | 15699112 (→Scopusで検索)
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| ○NAID (任意): |
| ○WOS (任意): | □ | 000226986700011
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Division of Molecular Immunology, Institute for Enzyme Research, University of Tokushima, Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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