『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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組織 (推奨): 1.徳島大学.工学部.生物工学科.生物機能工学講座 [継承]
著者 (必須): 1. (英) Kamaya Hiroshi (日) 釜谷 比羅志 (読) かまや ひろし
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2.金品 昌志
役割 (任意): (英)   (日) 解析,考察   [継承]
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3. (英) Ueda Issaku (日) 上田 一作 (読) うえだ いっさく
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題名 (必須): (英) Patition Equlibrium of Inhalation Anesthetics and Alcohols between Water and Membranes of Phospholipids with Varying Acyl - Chain Lengths  (日)    [継承]
副題 (任意):
要約 (任意): (英) From the depression of the phase-transition temperature of phospholipid membranes, the partition coefficients of inhalation anesthetics (methoxyflurane, halothane, enflurane, chloroform and diethyl ether) and alcohols (benzyl alcohol and homologous n-alcohols up to C = 7) between phospholipid vesicle membranes and water were determined. The phospholipids used were dimyristoyl-, dipalmitoyl- and distearoylphosphatidylcholines. It was found that the difference in the acyl chain length of the three phospholipids did not affect the partition coefficients of the inhalation anesthetics and benzyl alcohol. The actions of these drugs are apparently directed mainly to the interfacial region. In contrast, n-alcohols tend to bind more tightly to the phospholipid vesicles with longer acyl chains. The absolute values of the transfer free energies of n-alcohols increased with the increase of the length of the alkyl chain of the alcohols. The increment was 3.43 kJ per each carbon atom. The numerical values of the partition coefficients are not identical when different expressions for solute concentrations (mole fraction, molality and molarity) are employed. The conversion factors among these values were estimated from the molecular weights and the partial molal volumes of the phospholipids in aqueous solution determined by oscillation densimetry.  (日) リン脂質二分子膜の相転移温度を利用して吸入麻酔薬およびアルコール類の二分子膜相と水相間における分配係数を決定する方法について検討した.これらの薬物は二分子膜の液晶相に主として分配されるため,ゲル-液晶相転移温度は低下する.凝固点降下と類似の熱力学的取扱いにより,転移温度降下より分配係数を算出した.分配係数はリン脂質のアシル基鎖長の影響をほとんど受けない.   [継承]
キーワード (推奨): 1. (英) Alcohols (日) (読) [継承]
2. (英) Anesthetics (日) (読) [継承]
3. (英) Chloroform (日) (読) [継承]
4. (英) Enflurane (日) (読) [継承]
5. (英) Ether, Ethyl (日) (読) [継承]
6. (英) Halothane (日) (読) [継承]
7. (英) Membranes, Artificial (日) (読) [継承]
8. (英) Methoxyflurane (日) (読) [継承]
9. (英) Phosphatidylcholines (日) (読) [継承]
10. (英) Water (日) (読) [継承]
発行所 (推奨): Elsevier Science [継承]
誌名 (必須): Biochimica et Biophysica Acta (BBA) - Biomembranes ([Elsevier Science])
(pISSN: 0005-2736)

ISSN (任意): 0005-2736
ISSN: 0005-2736 (pISSN: 0005-2736, eISSN: 1879-2642)
Title: Biochimica et biophysica acta. Biomembranes
Title(ISO): Biochim Biophys Acta Biomembr
Publisher: Elsevier BV
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年月日 (必須): 西暦 1981年 8月 1日 (昭和 56年 8月 1日) [継承]
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DOI (任意): 10.1016/0005-2736(81)90280-7    (→Scopusで検索) [継承]
PMID (任意): 7272298    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, Non-P.H.S.  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.  (日)    [継承]

標準的な表示

和文冊子 ● Hiroshi Kamaya, Shoji Kaneshina and Issaku Ueda : Patition Equlibrium of Inhalation Anesthetics and Alcohols between Water and Membranes of Phospholipids with Varying Acyl - Chain Lengths, Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol.646, No.1, 135-142, 1981.
欧文冊子 ● Hiroshi Kamaya, Shoji Kaneshina and Issaku Ueda : Patition Equlibrium of Inhalation Anesthetics and Alcohols between Water and Membranes of Phospholipids with Varying Acyl - Chain Lengths, Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol.646, No.1, 135-142, 1981.

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