| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.神経情報医学部門.病態情報医学講座 (2004年4月1日〜)
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| ○著者 (必須): | 1. | (英) Suzaki Yuki (日) 須崎 友紀 (読) すざき ゆき
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| 2. | 吉栖 正典
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| 3. | (英) Yamashita Yukio (日) 山下 祐紀雄 (読) やました ゆきお
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| 4. | 阿部 真治 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.総合薬学教育学系.臨床薬学実務教育学])
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| 5. | 土屋 浩一郎 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.医薬品機能生化学]/[徳島大学.医学部.医学科.病態情報医学講座])
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| 6. | (英) Satoh Yumiko (日) (読)
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| 7. | 黒田 泰弘
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| 8. | (英) Horike Kazuya (日) (読)
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| 9. | 加納 正志
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| 10. | (英) Fukuta Yoshio (日) (読)
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| 11. | 北市 隆 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.外科系.心臓血管外科学])
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| 12. | 堀 隆樹
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| 13. | 増田 裕
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| 14. | 北川 哲也
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| 15. | 水口 和生
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| 16. | 玉置 俊晃
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| ○題名 (必須): | □ | (英) Determination of plasma concentrations of endothelin-1(1-31) and endothelin-1 in healthy subjects and patients with atherosclerosis. (日)
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| ○要約 (任意): | □ | (英) We previously found that human chymase cleaves big endothelins at the Tyr31-Gly32 bond and produces 31-amino-acid endothelins, endothelins(1-31). Endothelin-1(1-31) has been isolated from a number of human organs, including the heart and lungs. As endothelin-1 has been shown to play a significant role in the paracrine regulation of cardiovascular functions in humans, it is possible that endothelin-1(1-31) may also exhibit biological activity on human tissues. We previously reported that synthetic endothelin-1(1-31) exhibits a number of physiological actions on cultured cells in vitro. In the present study, we investigated the plasma concentrations of endothelin-1(1-31) and endothelin-1 in healthy subjects and compared them with those in patients with cardiovascular diseases. Endothelin-1(1-31) and endothelin-1 in human plasma was measured using a sandwich-enzyme-immunoassay system, which was recently described for measurement of endothelin-1(1-31). The plasma concentrations of endothelin-1(1-31) and endothelin-1 in healthy volunteers were 19.24 +/- 5.70 and 15.54 +/- 4.45 pg/ml (n = 5), respectively. We also measured plasma concentrations of endothelin-1(1-31) and endothelin-1 before and after surgery in patients with abdominal aortic aneurysms. Before surgery, plasma concentrations of endothelin-1(1-31) and endothelin-1 in these patients were higher than those in healthy individuals. After surgery, both endothelin-1(1-31) and endothelin-1 in plasma decreased to levels similar to those of healthy subjects. This suggests that endothelin-1(1-31) may have similar physiological significance to endothelin-1 in patients with atherosclerosis. (日)
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| ○キーワード (推奨): | 1. | (英) Adult (日) (読)
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| 2. | (英) Aged (日) (読)
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| 3. | (英) Aortic Aneurysm, Abdominal (日) (読)
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| 4. | (英) Arteriosclerosis (日) (読)
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| 5. | (英) Endothelin-1 (日) (読)
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| 6. | (英) Humans (日) (読)
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| 7. | (英) Male (日) (読)
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| 8. | (英) Middle Aged (日) (読)
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| 9. | (英) Peptide Fragments (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Journal of Cardiovascular Pharmacology ([Lippincott Williams & Wilkins])
(pISSN: 0160-2446, eISSN: 1533-4023)
| ○ISSN (任意): | □ | 0160-2446
ISSN: 0160-2446
(pISSN: 0160-2446, eISSN: 1533-4023) Title: Journal of cardiovascular pharmacologyTitle(ISO): J Cardiovasc PharmacolPublisher: Lippincott Williams & Wilkins Ltd. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 41
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| ○号 (必須): | □ | suppl.1
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| ○頁 (必須): | □ | S83 S87
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2003年 1月 初日 (平成 15年 1月 初日)
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| ○URL (任意): | □ | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12688403&dopt=Abstract
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| ○DOI (任意): |
| ○PMID (任意): | □ | 12688403 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000180132600017
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Department of Pharmacology, University of Tokushima School of Medicine, Tokushima, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Comparative Study (日)
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| 3. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 4. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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