| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部.附属動物実験施設 (->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門])
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| ○著者 (必須): | 1. | (英) Agui T (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | 松本 耕三
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| ○題名 (必須): | □ | (英) Direct demonstration of guanine nucleotide sensitive receptors for vasoactive intestinal peptide in the anterior lobe of the rat pituitary gland. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The vasoactive intestinal peptide (VIP) receptors were identified on the membranes from the rat anterior pituitary gland with [125I]VIP. The dissociation constant (Kd) and the maximal binding capacity (Bmax) values were estimated from the competitive inhibition data. The Kd and Bmax values were 1.05 +/- 0.75 nM and 103 +/- 11 fmol/mg protein, respectively. The order of molar potency of related peptides to inhibit [125I]VIP binding was VIP greater than peptide histidine isoleucine (PHI) greater than secretin greater than glucagon. Glucagon was not effective to inhibit the binding. [125I]VIP binding was effectively inhibited by the addition of guanine nucleotides. The order of molar potency to inhibit the binding was Gpp(NH)p greater than GTP greater than GDP greater than GMP greater than ATP. These results directly suggest the coupling of VIP receptors with guanine nucleotide binding proteins in the anterior pituitary gland. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Binding, Competitive (日) (読)
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| 3. | (英) Guanine Nucleotides (日) (読)
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| 4. | (英) Iodine Radioisotopes (日) (読)
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| 5. | (英) Male (日) (読)
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| 6. | (英) Pituitary Gland, Anterior (日) (読)
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| 7. | (英) Radioligand Assay (日) (読)
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| 8. | (英) Rats (日) (読)
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| 9. | (英) Rats, Inbred Strains (日) (読)
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| 10. | (英) Receptors, Gastrointestinal Hormone (日) (読)
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| 11. | (英) Receptors, Vasoactive Intestinal Peptide (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Peptides ([Elsevier])
(pISSN: 0196-9781, eISSN: 1873-5169)
| ○ISSN (任意): | □ | 0196-9781
ISSN: 0196-9781
(pISSN: 0196-9781, eISSN: 1873-5169) Title: PeptidesTitle(ISO): PeptidesPublisher: Elsevier Inc. (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 11
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 609 611
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1990年 5月 初日 (平成 2年 5月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/0196-9781(90)90065-D (→Scopusで検索)
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| ○PMID (任意): | □ | 2166281 (→Scopusで検索)
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.Affiliation: Institute for Animal Experimentation, University of Tokushima School of Medicine, Japan. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 3. | (英) MedlineDate: 1990 May-Jun (日)
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