| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部.附属動物実験施設 (->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門])
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| ○著者 (必須): | 1. | (英) Yamada T (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) Muramatsu Y (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 3. | (英) Agui T (日) (読)
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| ○学籍番号 (推奨): |
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| 4. | 松本 耕三
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| ○貢献度 (任意): |
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| ○題名 (必須): | □ | (英) A new restriction fragment length polymorphism of the ceruloplasmin gene in rat. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Using a cDNA probe of the ceruloplasmin (CP) gene, a new restriction fragment length polymorphism (RFLP) was detected in inbred strains of rat with the restriction enzyme KpnI. The RFLP behaved as a codominant trait on a single autosomal locus. Two alleles of the CP gene, which were tentatively designated as CP-A and CP-B, were almost equally distributed in 10 inbred strains. These indicate that the RFLP of the CP gene is a useful marker locus of the rat. We utilized this CP gene polymorphism for the investigation of the pathogenesis of the aberrant hepatic copper metabolism in LEC mutant rat, since CP has a pivotal role in copper metabolism in the liver. Using backcross progenies originating from LEC and BN rats, we found that the CP gene is not associated with the excess hepatic copper accumulation and the deficiency in serum CP activity, both of which are congenital abnormal phenotypes exhibited in LEC mutant rat. (日)
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| ○キーワード (推奨): | 1. | (英) Alleles (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Blotting, Southern (日) (読)
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| 4. | (英) Ceruloplasmin (日) (読)
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| 5. | (英) Copper (日) (読)
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| 6. | (英) Crosses, Genetic (日) (読)
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| 7. | (英) DNA Probes (日) (読)
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| 8. | (英) Liver (日) (読)
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| 9. | (英) Polymorphism, Restriction Fragment Length (日) (読)
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| 10. | (英) Rats (日) (読)
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| 11. | (英) Rats, Inbred Strains (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Biochemistry International (International Union of Biochemistry)
(pISSN: 0158-5231)
| ○ISSN (任意): | □ | 0158-5231
ISSN: 0158-5231
(pISSN: 0158-5231) Title: Biochemistry internationalTitle(ISO): Biochem IntPublisher: Academic Press Inc. (NLM Catalog)
(Scopus)
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| ○巻 (必須): | □ | 27
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 243 249
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1992年 7月 初日 (平成 4年 7月 初日)
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| ○URL (任意): |
| ○DOI (任意): |
| ○PMID (任意): | □ | 1354437 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 3. | (英) GeneSymbolList.GeneSymbol: CP (日)
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