| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部.附属動物実験施設 (->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門])
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| ○著者 (必須): | 1. | (英) Sakai T (日) (読)
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| 2. | (英) Agui T (日) (読)
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| 3. | (英) Muramatsu Y (日) (読)
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| 4. | (英) Yamada T (日) (読)
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| 5. | 松本 耕三
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| ○題名 (必須): | □ | (英) Dissociation of the interleukin-2 production from the cell activation in response to the mitogenic lectin in peripheral CD4+ T cells of LEC mutant rats. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) A mutant strain of rat, LEC, exhibits a novel maturational arrest of T cells in the thymus, that is, an arrest of the differentiation from CD4+ CD8+ to CD4+ CD8- cells. However, CD4+ T cells were found to arise in lymph nodes (LN) of LEC rats. These CD4+ T cells were T-cell receptor (TcR)/CD3+ and the cross-linking of either TcR alone or both TcR and CD4 molecules induced [3H]thymidine deoxyribose (TdR) incorporation, similar to functional CD4+ T cells. Stimulation with a T-cell mitogen, concanavalin A (Con A), also induced the [3H]TdR incorporation and interleukin-2 receptor (IL-2R) expression in LEC rat CD4+ T cells. Nevertheless, Con A stimulation did not induce IL-2 production by these cells. However, when the stimulation signals were bypassed by ionomycin and phorbol 12-myristate 13-acetate (PMA), IL-2 was normally produced, suggesting that the IL-2 gene and nuclear factors for the IL-2 gene transcription are normal in LEC rats. These results suggest that signals induced by Con A are separated into the one for IL-2 secretion and the other for cell activation including DNA synthesis and IL-2R expression, and that the former signal transduction is blocked in LEC rat CD4+ T cells. Thus, CD4+ T cells in LEC rat LN might provide a good tool for investigating the regulatory mechanisms of IL-2 production. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) CD4-Positive T-Lymphocytes (日) (読)
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| 3. | (英) Cells, Cultured (日) (読)
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| 4. | (英) Concanavalin A (日) (読)
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| 5. | (英) Interleukin-1 (日) (読)
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| 6. | (英) Interleukin-2 (日) (読)
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| 7. | (英) Ionomycin (日) (読)
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| 8. | (英) Lymph Nodes (日) (読)
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| 9. | (英) Lymphocyte Activation (日) (読)
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| 10. | (英) Rats (日) (読)
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| 11. | (英) Rats, Mutant Strains (日) (読)
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| 12. | (英) Receptors, Antigen, T-Cell (日) (読)
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| 13. | (英) Receptors, Interleukin-2 (日) (読)
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| 14. | (英) Tetradecanoylphorbol Acetate (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Immunology (British Society for Immunology)
(pISSN: 0019-2805, eISSN: 1365-2567)
| ○ISSN (任意): | □ | 0019-2805
ISSN: 0019-2805
(pISSN: 0019-2805, eISSN: 1365-2567) Title: ImmunologyTitle(ISO): ImmunologySupplier: British Society for ImmunologyPublisher: Wiley Publishing (NLM Catalog)
(Wiley)
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| ○巻 (必須): | □ | 79
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 491 497
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1993年 7月 初日 (平成 5年 7月 初日)
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| ○URL (任意): |
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| ○PMID (任意): | □ | 8104885 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-0027314036
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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