| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部.附属動物実験施設 (->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門])
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| ○著者 (必須): | 1. | (英) Sakai T (日) (読)
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| ○貢献度 (任意): |
| ○学籍番号 (推奨): |
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| 2. | (英) Agui T (日) (読)
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| 3. | 松本 耕三
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| ○題名 (必須): | □ | (英) Intestinal intra-epithelial lymphocytes in LEC mutant rats. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) LEC rat is a novel strain showing a maturational arrest from CD4+8+ to CD4+8- cells but not to CD4-8+ cells in the thymus. In this study, we examined if this mutation affects the differentiation of intestinal intra-epithelial lymphocytes (IEL) in LEC rats. In normal rat IEL, all 4 subsets with respect to the CD4/CD8 expression were observed. The CD4-8+ population was dominant and a unique population, CD4+8+, was observed as already shown in previous papers. Both CD4+8- and CD4+8+ cells were CD3+, TCR-alpha/beta +, CD45RC-, and CD5+, whereas CD4-8+ cells consisted of a heterogeneous population, being CD3+, TCR-alpha/beta +/-, CD45RC+/-, and CD5-. In LEC rat IEL, CD4+8- and CD4+8+ cells existed normally and distribution of CD4/CD8 subsets was not different from that of normal rat IEL. Furthermore, the expression pattern of CD3, TCR-alpha/beta, CD45RC and CD5 was not different from that of normal rat IEL in each subset. These results suggest that maturational arrest of CD4+8- thymocytes does not affect IEL maturation, especially maturation of CD4+8- IEL, suggesting that the IEL maturation mechanism for CD4+8- cells is independent of that of thymocytes. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antigens, Differentiation (日) (読)
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| 3. | (英) Cell Differentiation (日) (読)
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| 4. | (英) Flow Cytometry (日) (読)
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| 5. | (英) Intestinal Mucosa (日) (読)
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| 6. | (英) Rats (日) (読)
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| 7. | (英) Rats, Inbred F344 (日) (読)
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| 8. | (英) Rats, Mutant Strains (日) (読)
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| 9. | (英) T-Lymphocyte Subsets (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Immunology Letters (European Federation of Immunological Societies)
(pISSN: 0165-2478, eISSN: 1879-0542)
| ○ISSN (任意): | □ | 0165-2478
ISSN: 0165-2478
(pISSN: 0165-2478, eISSN: 1879-0542) Title: Immunology lettersTitle(ISO): Immunol LettPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 41
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| ○号 (必須): | □ | 2-3
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| ○頁 (必須): | □ | 185 189
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1994年 7月 初日 (平成 6年 7月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/0165-2478(94)90130-9 (→Scopusで検索)
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| ○PMID (任意): | □ | 8002035 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-0027984721
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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