| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部.附属動物実験施設 (->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門])
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| ○著者 (必須): | 1. | (英) Muramatsu Y (日) (読)
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| 2. | (英) Yamada T (日) (読)
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| 3. | (英) Miura M (日) (読)
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| 4. | (英) Sakai T (日) (読)
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| 5. | (英) Suzuki Y (日) (読)
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| 6. | (英) Serikawa T (日) (読)
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| 7. | (英) Tanzi R (日) (読)
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| 8. | 松本 耕三
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| ○題名 (必須): | □ | (英) Wilson's disease gene is homologous to hts causing abnormal copper transport in Long-Evans-Cinnamon rats. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) The Long-Evans Cinnamon (LEC) mutant rat shows an excess copper accumulation in the liver and low serum ceruloplasmin activity. The disorder is controlled by a single autosomal recessive gene designated as hts. Wilson's disease is an autosomal recessive disorder of copper metabolism characterized by abnormal copper accumulation in the liver and low serum ceruloplasmin activity. The gene responsible for Wilson's disease has recently been isolated. The present study was designed to examine whether the LEC rat is an ideal animal model for Wilson's disease from a genetic point of view. For chromosomal mapping of hts, genetic linkage analysis using rat microsatellite marker loci was performed. Furthermore, cosegregation between hts and a rat counterpart of the Wilson's disease gene was analyzed. hts was finely mapped to rat chromosome 16. Complete cosegregation between hts and a rat counterpart of the Wilson's disease gene was detected. hts is likely to correspond to a rat homologue of the Wilson's disease gene. The present results allow us to propose that the LEC rat is an ideal animal model for Wilson's disease. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Base Sequence (日) (読)
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| 3. | (英) Biological Transport (日) (読)
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| 4. | (英) Chromosome Mapping (日) (読)
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| 5. | (英) Copper (日) (読)
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| 6. | (英) Genes, Recessive (日) (読)
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| 7. | (英) Hepatolenticular Degeneration (日) (読)
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| 8. | (英) Molecular Probes (日) (読)
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| 9. | (英) Molecular Sequence Data (日) (読)
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| 10. | (英) Polymerase Chain Reaction (日) (読)
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| 11. | (英) Rats (日) (読)
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| 12. | (英) Rats, Inbred Strains (日) (読)
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| 13. | (英) Sequence Homology (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Gastroenterology (American Gastroenterological Association)
(pISSN: 0016-5085, eISSN: 1528-0012)
| ○ISSN (任意): | □ | 0016-5085
ISSN: 0016-5085
(pISSN: 0016-5085, eISSN: 1528-0012) Title: GastroenterologyTitle(ISO): GastroenterologyPublisher: W.B. Saunders (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 107
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 1189 1192
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1994年 10月 初日 (平成 6年 10月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/0016-5085(94)90247-X (→Scopusで検索)
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| ○PMID (任意): | □ | 7926469 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-0027981529
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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