| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部.附属動物実験施設 (->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門])
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| ○著者 (必須): | 1. | (英) Muramatsu Y (日) (読)
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| 2. | (英) Agui T (日) (読)
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| 3. | (英) Yamada T (日) (読)
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| 4. | 松本 耕三
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| ○題名 (必須): | □ | (英) The diversity of T-cell receptor repertoire of peripheral CD4+ lymphocytes in LEC mutant rats. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) A novel mutant strain of rats, LEC, exhibits an arrest of T-cell maturation from CD4+CD8+ to CD4+CD8- but not the CD4-CD8+ cells in the thymus. Nevertheless, CD4+T cells arise in lymph nodes of LEC rats, implying extrathymic T-cell maturation. We analyzed the variable (V) and junctional region diversity of T-cell receptor (TCR) beta- chains in this population, since several reports have provided evidence that extrathymically matured T cells exhibit a biased expression of the TCR repertoire. CD4+ T cells in LEC rat lymph nodes exhibited a polymorphic V beta gene expression pattern. However, biased V beta gene expression was not identified in peripheral CD4+ T cells of LEC rats when compared with V beta gene expression in their thymocytes. Furthermore, junctional regions of TCR beta chains exhibited a vast diversity created by non-germline- encoded nucleotide (N nucleotide) additions. These results indicate that peripheral CD4+ T cells in LEC rats possess a vast diversity in the TCR repertoire as do thymocytes of the same rat, suggesting that they derive from the thymus. (日)
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| ○キーワード (推奨): | 1. | (英) Amino Acid Sequence (日) (読)
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| 2. | (英) Animals (日) (読)
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| 3. | (英) Base Sequence (日) (読)
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| 4. | (英) CD4-Positive T-Lymphocytes (日) (読)
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| 5. | (英) Cells, Cultured (日) (読)
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| 6. | (英) Gene Expression (日) (読)
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| 7. | (英) Lymph Nodes (日) (読)
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| 8. | (英) Mesentery (日) (読)
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| 9. | (英) Molecular Sequence Data (日) (読)
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| 10. | (英) Polymerase Chain Reaction (日) (読)
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| 11. | (英) Polymorphism, Genetic (日) (読)
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| 12. | (英) Rats (日) (読)
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| 13. | (英) Rats, Mutant Strains (日) (読)
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| 14. | (英) Receptors, Antigen, T-Cell, alpha-beta (日) (読)
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| 15. | (英) Thymus Gland (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Immunology Letters (European Federation of Immunological Societies)
(pISSN: 0165-2478, eISSN: 1879-0542)
| ○ISSN (任意): | □ | 0165-2478
ISSN: 0165-2478
(pISSN: 0165-2478, eISSN: 1879-0542) Title: Immunology lettersTitle(ISO): Immunol LettPublisher: Elsevier B.V. (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 45
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| ○号 (必須): | □ | 3
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| ○頁 (必須): | □ | 173 177
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1995年 3月 初日 (平成 7年 3月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/0165-2478(94)00254-O (→Scopusで検索)
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| ○PMID (任意): | □ | 7558170 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-0028937245
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| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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| 3. | (英) GeneSymbolList.GeneSymbol: TCR (日)
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