『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=113563)

EID=113563EID:113563, Map:0, LastModified:2025年9月18日(木) 18:30:56, Operator:[大家 隆弘], Avail:TRUE, Censor:承認済, Owner:[[学科長]/[徳島大学.医学部.医学科]], Read:継承, Write:継承, Delete:継承.
○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨): □Peer Review [継承]
○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨): 1.徳島大学.医学部.附属動物実験施設 (->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門]) [継承]
○著者 (必須): 1. (英) Sakai T (日) (読)
○役割 (任意):
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○学籍番号 (推奨):
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2. (英) Agui T (日) (読)
○役割 (任意):
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○学籍番号 (推奨):
[継承]
3.松本 耕三
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○題名 (必須): □(英) Abnormal CD45RC expression and elevated CD45 protein tyrosine phosphatase activity in LEC rat peripheral CD4+ T Cells.  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) LEC rats are known to show a maturational arrest in the development of CD4+8+ to CD4+8- cells in the thymus. Despite the blockade of maturation of CD4+8-thymocytes, CD4+ T cells were observed in peripheral lymphoid organs, and these cells exhibit a defect in interleukin-2 (IL-2) production upon concanavalin A (Con A) stimulation. Although peripheral CD4+ cells in normal rat highly expressed CD45RC (CD45RChigh), the level of CD45RC expression was low (CD45RClow) in LEC rat peripheral CD4+ cells. However, CD4+ cells from both strains highly expressed CD45 when those cells were stained by pan-CD45 mAb, suggesting that LEC rat CD4+ cells are deficient in expression of the CD45RC isoform, but not of CD45 molecules. When backcross rats from (F344 x LEC)F1 x LEC were examined, the phenotype for CD45 expression pattern in CD4+ cells was clearly correlated with IL-2 production level in response to Con A stimulation. Thus, CD45RClow cells exhibit a defect in IL-2 production, while CD45RChigh cells show normal IL-2 production. Protein tyrosine phosphatase (PTPase) activity in the membrane fraction of LEC rat CD4+ cells was threefold higher than that of normal rat CD4+ cells. Con A stimulation led to an increase in tyrosine phosphorylation levels, especially 100- and 40-kDa proteins, in normal rat CD4+ cells. In LEC rat CD4+ cells, however, the level of tyrosine phosphorylation in those proteins were very low. These results suggest that an elevated CD45 PTPase activity is responsive for a defect in IL-2 production in LEC rat peripheral CD4+ T cells.  (日)    [継承]
○キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) CD4-Positive T-Lymphocytes (日) (読) [継承]
3. (英) Cell Differentiation (日) (読) [継承]
4. (英) Concanavalin A (日) (読) [継承]
5. (英) Enzyme Induction (日) (読) [継承]
6. (英) Gene Expression Regulation (日) (読) [継承]
7. (英) Immunologic Deficiency Syndromes (日) (読) [継承]
8. (英) Interleukin-2 (日) (読) [継承]
9. (英) Isoenzymes (日) (読) [継承]
10. (英) Leukocyte Common Antigens (日) (読) [継承]
11. (英) Lymphocyte Activation (日) (読) [継承]
12. (英) Lymphocyte Subsets (日) (読) [継承]
13. (英) Phosphorylation (日) (読) [継承]
14. (英) Protein Processing, Post-Translational (日) (読) [継承]
15. (英) Protein Tyrosine Phosphatases (日) (読) [継承]
16. (英) RNA Splicing (日) (読) [継承]
17. (英) Rats (日) (読) [継承]
18. (英) Rats, Inbred F344 (日) (読) [継承]
19. (英) Rats, Mutant Strains (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □European Journal of Immunology (European Federation of Immunological Societies)
(pISSN: 0014-2980, eISSN: 1521-4141)

○ISSN (任意): □0014-2980
ISSN: 0014-2980 (pISSN: 0014-2980, eISSN: 1521-4141)
Title: European journal of immunology
Title(ISO): Eur J Immunol
Supplier: European Federation of Immunological Societies
Publisher: Wiley
 (NLM Catalog)   (Wiley)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □25 [継承]
○号 (必須): □5 [継承]
○頁 (必須): □1399 1404 [継承]
○都市 (任意):
○年月日 (必須): □西暦 1995年 5月 初日 (平成 7年 5月 初日) [継承]
○URL (任意):
○DOI (任意): □10.1002/eji.1830250539    (→Scopusで検索) [継承]
○PMID (任意): □7774643    (→Scopusで検索) [継承]
○CRID (任意):
○Scopus (任意): 1.2-s2.0-0029042546 [継承]
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○備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● T Sakai, T Agui and Kozo Matsumoto : Abnormal CD45RC expression and elevated CD45 protein tyrosine phosphatase activity in LEC rat peripheral CD4+ T Cells., European Journal of Immunology, 25, 5, 1399-1404, 1995.
欧文冊子 ● T Sakai, T Agui and Kozo Matsumoto : Abnormal CD45RC expression and elevated CD45 protein tyrosine phosphatase activity in LEC rat peripheral CD4+ T Cells., European Journal of Immunology, 25, 5, 1399-1404, 1995.

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