| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.医学部.附属動物実験施設 (->組織[徳島大学.大学院ヘルスバイオサイエンス研究部.総合研究支援センター.動物資源研究部門])
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| ○著者 (必須): | 1. | (英) Sakai Tohru (日) (読)
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| ○貢献度 (任意): |
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| 2. | (英) Agui Takashi (日) (読)
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| 3. | (英) Muramatsu Youji (日) (読)
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| 4. | (英) Yamada Takahisa (日) (読)
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| 5. | (英) Hisaeda Hajime (日) (読)
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| 6. | (英) Himeno Hunisuke (日) (読)
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| 7. | 松本 耕三
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| ○題名 (必須): | □ | (英) Function of CD4 molecules in LEC rat thymocytes. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Long-Evans Cinnamon (LEC) rats show a novel maturational arrest from CD4+8+ to CD4+8- thymocytes but a cause of this mutation is not identified. The candidate for this mutation is a defect in the function of CD4 or major histocompatibility complex (MHC) class II because gene-disrupted mice defective for CD4 or MHC class II molecules show a specific defect in CD4+ T cells. Previously, we showed that MHC class II is not a cause of this maturational arrest. Therefore, in this study, we focus on the function of CD4 molecules in LEC rat thymocytes. CD4 molecules on LEC rat thymocytes associated with protein tyrosine kinase, p56[lck], normally. Furthermore, cross-linking of CF4 molecules by anti-rat CD4 mAb elicited the elevation of intracellular calcium concentrations ([Ca2+]i) in LEC rat thymocytes, suggesting that CD4 molecules can deliver the signal normally. These results indicate that function of CD4 is normal and the maturational blockade of CD4+8- thymocytes in LEC rats is not caused by specific lymphocyte molecules that have been shown in gene-disrupted mice. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Antibodies, Monoclonal (日) (読)
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| 3. | (英) CD4 Antigens (日) (読)
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| 4. | (英) CD8 Antigens (日) (読)
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| 5. | (英) Calcium (日) (読)
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| 6. | (英) Mutation (日) (読)
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| 7. | (英) Protein-Tyrosine Kinases (日) (読)
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| 8. | (英) Rats (日) (読)
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| 9. | (英) Rats, Inbred F344 (日) (読)
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| 10. | (英) Rats, Inbred Strains (日) (読)
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| 11. | (英) Thymus Gland (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | The Journal of Veterinary Medical Science ([社団法人 日本獣医学会])
(pISSN: 0916-7250, eISSN: 1347-7439)
| ○ISSN (任意): | □ | 0916-7250
ISSN: 0916-7250
(pISSN: 0916-7250, eISSN: 1347-7439) Title: The Journal of veterinary medical scienceTitle(ISO): J Vet Med SciSupplier: 社団法人日本獣医学会Publisher: Japanese Society of Veterinary Science (NLM Catalog)
(CiNii NCID)
(医中誌Web)
(J-STAGE)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 58
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| ○号 (必須): | □ | 11
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| ○頁 (必須): | □ | 1125 1127
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1996年 11月 初日 (平成 8年 11月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1292/jvms.58.11_1125 (→Scopusで検索)
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| ○PMID (任意): | □ | 8959663 (→Scopusで検索)
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| ○CRID (任意): |
| ○Scopus (任意): | 1. | 2-s2.0-0030278868
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| ○researchmap (任意): |
| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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