『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
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カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨): 1.徳島大学.分子酵素学研究センター (〜2007年3月31日/->組織[徳島大学.疾患酵素学研究センター]) [継承]
著者 (必須): 1.湯浅 智之 ([徳島大学.大学院医歯薬学研究部.医学域.連携研究部門(医学域).寄附講座系(医学域).実践地域診療・医科学])
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2. (英) Kakuhata Rei (日) (読)
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[継承]
3.岸 和弘
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4.小畑 利之
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5.篠原 康雄 ([徳島大学.先端酵素学研究所.基幹研究部門])
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6.坂東 良美 ([徳島大学.病院.中央診療施設等.病理部])
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7.泉 啓介
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8. (英) Kajiura Fumiko (日) (読)
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9.松本 満 ([徳島大学.先端酵素学研究所.重点研究部門])
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10.蛯名 洋介
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題名 (必須): (英) Platelet-derived growth factor stimulates glucose transport in skeletal muscles of transgenic mice specifically expressing PDGF receptor in the muscle, but does not affect blood glucose levels  (日)    [継承]
副題 (任意):
要約 (任意): (英) Insulin stimulates the disposal of blood glucose into skeletal muscle and adipose tissues by the translocation of GLUT4 from intracellular pools to the plasma membrane, and consequently the concentration of blood glucose levels decreases rapidly in vivo. Phosphatidylinositol (PI) 3-kinase and Akt play a pivotal role in the stimulation of glucose transport by insulin, but detailed mechanisms are unknown. We and others reported that not only insulin but also platelet-derived growth factor (PDGF) and epidermal growth factor facilitate glucose uptake through GLUT4 translocation by activation of PI 3-kinase and Akt in cultured cells. However, opposite results were also reported. We generated transgenic mice that specifically express the PDGF receptor in skeletal muscle. In these mice, PDGF stimulated glucose transport into skeletal muscle in vitro and in vivo. Thus, PDGF apparently shares with insulin some of the signaling molecules needed for the stimulation of glucose transport. The degree of glucose uptake in vivo reached approximately 60% of that by insulin injection in skeletal muscle, but blood glucose levels were not decreased by PDGF in these mice. Therefore, PDGF-induced disposal of blood glucose into skeletal muscle is insufficient for rapid decrease of blood glucose levels.  (日)    [継承]
キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Biological Transport (日) (読) [継承]
3. (英) Blood Glucose (日) (読) [継承]
4. (英) Glucose (日) (読) [継承]
5. (英) Heart (日) (読) [継承]
6. (英) Insulin (日) (読) [継承]
7. (英) Mice (日) (読) [継承]
8. (英) Mice, Transgenic (日) (読) [継承]
9. (英) Muscle, Skeletal (日) (読) [継承]
10. (英) Platelet-Derived Growth Factor (日) (読) [継承]
11. (英) Receptor, Platelet-Derived Growth Factor beta (日) (読) [継承]
12. (英) Recombinant Proteins (日) (読) [継承]
13. (英) Signal Transduction (日) (読) [継承]
発行所 (推奨): The American Diabetes Association [継承]
誌名 (必須): Diabetes ([The American Diabetes Association])
(pISSN: 0012-1797, eISSN: 1939-327X)

ISSN (任意): 0012-1797
ISSN: 0012-1797 (pISSN: 0012-1797, eISSN: 1939-327X)
Title: Diabetes
Title(ISO): Diabetes
Publisher: American Diabetes Association
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 2776 2786 [継承]
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年月日 (必須): 西暦 2004年 11月 初日 (平成 16年 11月 初日) [継承]
URL (任意):
DOI (任意): 10.2337/diabetes.53.11.2776    (→Scopusで検索) [継承]
PMID (任意): 15504957    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Division of Molecular Genetics, Institute for Enzyme Research, the University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]

標準的な表示

和文冊子 ● Tomoyuki Yuasa, Rei Kakuhata, Kazuhiro Kishi, Toshiyuki Obata, Yasuo Shinohara, Yoshimi Bando, Keisuke Izumi, Fumiko Kajiura, Mitsuru Matsumoto and Yousuke Ebina : Platelet-derived growth factor stimulates glucose transport in skeletal muscles of transgenic mice specifically expressing PDGF receptor in the muscle, but does not affect blood glucose levels, Diabetes, Vol.53, No.11, 2776-2786, 2004.
欧文冊子 ● Tomoyuki Yuasa, Rei Kakuhata, Kazuhiro Kishi, Toshiyuki Obata, Yasuo Shinohara, Yoshimi Bando, Keisuke Izumi, Fumiko Kajiura, Mitsuru Matsumoto and Yousuke Ebina : Platelet-derived growth factor stimulates glucose transport in skeletal muscles of transgenic mice specifically expressing PDGF receptor in the muscle, but does not affect blood glucose levels, Diabetes, Vol.53, No.11, 2776-2786, 2004.

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