『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=111390EID:111390, Map:0, LastModified:2013年9月8日(日) 19:29:09, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[山﨑 尚志], Read:継承, Write:継承, Delete:継承.
種別 (必須): 総説·解説 [継承]
言語 (必須): 英語 [継承]
招待 (推奨): 依頼 [継承]
審査 (推奨):
カテゴリ (推奨): 研究 [継承]
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨): 1.徳島大学.薬学部.製薬化学科.薬品素材学講座 (〜2006年3月31日) [継承]
著者 (必須): 1.山﨑 尚志 ([徳島大学.大学院医歯薬学研究部.薬学域.薬科学部門.生命薬学系.薬物治療学])
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学籍番号 (推奨):
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題名 (必須): (英) Identification of Muscle-Type Carnitine Palmitoyltransferase I and Characterization of Its Atypical Gene Structure  (日)    [継承]
副題 (任意):
要約 (任意): (英) To characterize energy metabolism in rat brown adipose tissue (BAT), we carried out differential screening of a cDNA library of BAT with a cDNA probe of white adipose tissue and isolated one novel cDNA clone. It contained a single open-reading frame of 2316 bases, which encodes a protein of 88.2 kDa. The predicted amino acid sequence showed the highest homology (62.6%) with that of carnitine palmitoyltransferase I (CPTI) from rat liver. The transcript corresponding to this cDNA was found to be abundantly expressed not only in BAT but also in heart and skeletal muscle. CPTI is known to be a protein necessary for the beta-oxidation of long-chain fatty acids in mammalian mitochondria, and it has been suggested that at least two isoforms, the liver type and muscle type, exist. From these observations, a cDNA clone isolated from rat BAT was concluded to be encoding muscle-type CPTI (M-CPTI). Characterization of a genomic DNA clone revealed that the gene for human M-CPTI consists of two 5'-noncoding exons, 18 coding exons, and one 3'-noncoding exon spanning approximately 10 kbp, and a gene encoding choline/ethanolamine kinase-beta (CK/EK-beta) was located only about 300 bp upstream from the M-CPTI gene with the same strand direction. Furthermore, we found that unordinary transcripts containing exons of both CK/EK-beta and M-CPTI genes exist in human and rodent tissues. Although the physiologic role(s) of these transcripts is still unknown, it is interesting that such transcripts are produced from two tightly arranged and functionally unrelated genes.  (日)    [継承]
キーワード (推奨): 1. (英) Adipose Tissue, Brown (日) (読) [継承]
2. (英) Amino Acid Sequence (日) (読) [継承]
3. (英) Animals (日) (読) [継承]
4. (英) Carnitine O-Palmitoyltransferase (日) (読) [継承]
5. (英) Energy Metabolism (日) (読) [継承]
6. (英) Humans (日) (読) [継承]
7. (英) Isoenzymes (日) (読) [継承]
8. (英) Liver (日) (読) [継承]
9. (英) Molecular Sequence Data (日) (読) [継承]
10. (英) Muscle, Skeletal (日) (読) [継承]
11. (英) Muscle, Smooth (日) (読) [継承]
12. (英) Myocardium (日) (読) [継承]
13. (英) Organ Specificity (日) (読) [継承]
14. (英) Rats (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Biological & Pharmaceutical Bulletin ([日本薬学会])
(pISSN: 0918-6158, eISSN: 1347-5215)

ISSN (任意): 0918-6158
ISSN: 0918-6158 (pISSN: 0918-6158, eISSN: 1347-5215)
Title: Biological & pharmaceutical bulletin
Title(ISO): Biol Pharm Bull
Supplier: 公益社団法人日本薬学会
Publisher: Pharmaceutical Society of Japan
 (NLM Catalog  (Webcat Plus  (医中誌Web  (J-STAGE  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 27 [継承]
(必須): 11 [継承]
(必須): 1707 1716 [継承]
都市 (任意):
年月日 (必須): 西暦 2004年 11月 初日 (平成 16年 11月 初日) [継承]
URL (任意):
DOI (任意): 10.1248/bpb.27.1707    (→Scopusで検索) [継承]
PMID (任意): 15516711    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Article.Affiliation: Faculty of Pharmaceutical Sciences, University of Tokushima, Japan. yamazaki@ph.tokushima-u.ac.jp  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Review  (日)    [継承]
5.(英) NumberOfReferences: 46  (日)    [継承]

標準的な表示

和文冊子 ● Naoshi Yamazaki : Identification of Muscle-Type Carnitine Palmitoyltransferase I and Characterization of Its Atypical Gene Structure, Biological & Pharmaceutical Bulletin, Vol.27, No.11, 1707-1716, Nov. 2004.
欧文冊子 ● Naoshi Yamazaki : Identification of Muscle-Type Carnitine Palmitoyltransferase I and Characterization of Its Atypical Gene Structure, Biological & Pharmaceutical Bulletin, Vol.27, No.11, 1707-1716, Nov. 2004.

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