『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=104283EID:104283, Map:0, LastModified:2019年2月19日(火) 15:25:58, Operator:[三木 ちひろ], Avail:TRUE, Censor:0, Owner:[[研究部長]/[徳島大学.大学院ヘルスバイオサイエンス研究部]], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
共著種別 (推奨):
学究種別 (推奨):
組織 (推奨):
著者 (必須): 1. (英) Kawashima Yoshiaki (日) (読)
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2. (英) Iwamoto Taro (日) (読)
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3. (英) Niwa Toshiyuki (日) (読)
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4. (英) Takeuchi Hirofumi (日) (読)
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5.日野 知証
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題名 (必須): (英) Role of the solvent-diffusion-rate modifier in a new emulsion solvent diffusion method for preparation of ketoprofen microspheres  (日)    [継承]
副題 (任意):
要約 (任意): (英) A new emulsion solvent diffusion method to prepare the microspheres of ketoprofen with an acrylic polymer was developed by utilizing sugar esters as solvent diffusion modifiers. The microspheres were produced via transient o/w emulsion droplets of the polymer, which was formed by the interaction of drug and water-miscible organic solvent, e.g. ethanol. The solvent consisting in oil droplets diffused into the outer aqueous medium. In the droplets, ethanol interacted with ketoprofen via hydrogen bonding between -OH group of ethanol and both -COOH and = CO groups of ketoprofen. These hydrogen bonds made ethanol solution strongly hydrophobic. The sugar ester added in the ethanol could inhibit such intermolecular interaction between ethanol and the = CO group of ketoprofen. Modulation in the binding force of ketoprofen-ethanol by the sugar ester contributed to achieving a desirable initial ethanol diffusion rate from the oil droplets for the formation of ketoprofen microspheres with high yield (> 85 per cent) and drug entrapment ratio (> 90 per cent).  (日)    [継承]
キーワード (推奨): 1. (英) Acrylates (日) (読) [継承]
2. (英) Carbohydrates (日) (読) [継承]
3. (英) Chemistry, Pharmaceutical (日) (読) [継承]
4.拡散 (diffusion) [継承]
5. (英) Drug Compounding (日) (読) [継承]
6. (英) Emulsions (日) (読) [継承]
7. (英) Esters (日) (読) [継承]
8.メタノール (methanol) [継承]
9. (英) Ibuprofen (日) (読) [継承]
10. (英) Ketoprofen (日) (読) [継承]
11. (英) Microspheres (日) (読) [継承]
12. (英) Solvents (日) (読) [継承]
13. (英) Water (日) (読) [継承]
発行所 (推奨):
誌名 (必須): Journal of Microencapsulation (International Microencapsulation Society)
(pISSN: 0265-2048, eISSN: 1464-5246)

ISSN (任意): 0265-2048
ISSN: 0265-2048 (pISSN: 0265-2048, eISSN: 1464-5246)
Title: Journal of microencapsulation
Title(ISO): J Microencapsul
Publisher: Taylor & Francis
 (NLM Catalog  (Scopus  (CrossRef (Scopus information is found. [need login])
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(必須): 10 [継承]
(必須): 3 [継承]
(必須): 329 340 [継承]
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年月日 (必須): 西暦 1993年 0月 初日 (平成 5年 0月 初日) [継承]
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DOI (任意): 10.3109/02652049309031523    (→Scopusで検索) [継承]
PMID (任意): 8377091    (→Scopusで検索) [継承]
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Scopus (任意): 2-s2.0-0027197524 [継承]
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備考 (任意): 1.(英) Article.PublicationTypeList.PublicationType: Comparative Study  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) MedlineDate: 1993 Jul-Sep  (日)    [継承]

標準的な表示

和文冊子 ● Yoshiaki Kawashima, Taro Iwamoto, Toshiyuki Niwa, Hirofumi Takeuchi and Tomoaki Hino : Role of the solvent-diffusion-rate modifier in a new emulsion solvent diffusion method for preparation of ketoprofen microspheres, Journal of Microencapsulation, Vol.10, No.3, 329-340, 1993.
欧文冊子 ● Yoshiaki Kawashima, Taro Iwamoto, Toshiyuki Niwa, Hirofumi Takeuchi and Tomoaki Hino : Role of the solvent-diffusion-rate modifier in a new emulsion solvent diffusion method for preparation of ketoprofen microspheres, Journal of Microencapsulation, Vol.10, No.3, 329-340, 1993.

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