『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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登録内容 (EID=104121)

EID=104121EID:104121, Map:0, LastModified:2013年9月11日(水) 21:11:57, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[石川 康子], Read:継承, Write:継承, Delete:継承.
種別 (必須): 学術論文 (審査論文) [継承]
言語 (必須): 英語 [継承]
招待 (推奨):
審査 (推奨):
カテゴリ (推奨):
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学究種別 (推奨):
組織 (推奨):
著者 (必須): 1.石川 康子
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学籍番号 (推奨):
[継承]
2. (英) Malcolm V. Gee (日) (読)
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[継承]
3. (英) Indu S. Ambudkar (日) (読)
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[継承]
4. (英) Lipa Bodner (日) (読)
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[継承]
5. (英) Bruce J. Baum (日) (読)
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[継承]
題名 (必須): (英) Age-related impairment in rat parotid cell 1-adrenergic action at the level of inositol trisphosphate responsiveness.  (日)    [継承]
副題 (任意):
要約 (任意): (英) Alpha 1-Adrenergic-stimulated calcium efflux from rat parotid cell aggregates declines approx. 40% between 3 and 24 months of age, with the bulk of the reduction occurring between 12 and 24 months. Intracellular free calcium levels following alpha 1-adrenoceptor stimulation are also reduced about 40% between 3 and 24 months. No significant age differences in stimulation of inositol mono-, bis- or trisphosphate production are observed. However, the ability of inositol trisphosphate to directly stimulate calcium efflux is reduced by about 50% with increasing age. Concentrations of this inositol phosphate required for maximal calcium release do not change between 3 and 24 months. Differences in response are not due to a reduction in uptake of inositol trisphosphate into older cells, but suggest an age-related defect in the ability of inositol trisphosphate to liberate calcium from intracellular stores. Such dysfunction may be at least partially responsible for impaired alpha 1-adrenergic responsiveness during aging.  (日)    [継承]
キーワード (推奨): 1.顎口腔機能 (stomatognathic function) [継承]
2.加齢変化 (aging patterrn) [継承]
3.情報伝達機構 (signal transduction) [継承]
4.神経伝達物質 (neurotransmitter) [継承]
5.カルシウム (calcium) [継承]
発行所 (推奨):
誌名 (必須): Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ([Elsevier Science])
(pISSN: 0167-4889)

ISSN (任意): 0167-4889
ISSN: 0167-4889 (pISSN: 0167-4889, eISSN: 1879-2596)
Title: Biochimica et biophysica acta. Molecular cell research
Title(ISO): Biochim Biophys Acta Mol Cell Res
Publisher: Elsevier BV
 (NLM Catalog  (CrossRef (Scopus information is found. [need login])
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年月日 (必須): 西暦 1988年 2月 22日 (昭和 63年 2月 22日) [継承]
URL (任意):
DOI (任意): 10.1016/0167-4889(88)90009-2    (→Scopusで検索) [継承]
PMID (任意): 2829980    (→Scopusで検索) [継承]
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備考 (任意): 1.(英) Biochimica et Biophysica Acta (BBA) - Molecular Cell Research  (日)    [継承]

標準的な表示

和文冊子 ● Yasuko Ishikawa, Gee V. Malcolm, Ambudkar S. Indu, Bodner Lipa and Baum J. Bruce : Age-related impairment in rat parotid cell 1-adrenergic action at the level of inositol trisphosphate responsiveness., Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol.968, No.2, 203-210, 1988.
欧文冊子 ● Yasuko Ishikawa, Gee V. Malcolm, Ambudkar S. Indu, Bodner Lipa and Baum J. Bruce : Age-related impairment in rat parotid cell 1-adrenergic action at the level of inositol trisphosphate responsiveness., Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol.968, No.2, 203-210, 1988.

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