| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Lu FW (日) (読)
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| 2. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| 3. | (英) Goodman GB (日) (読)
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| 4. | (英) McHeyzer-Williams LJ (日) (読)
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| 5. | (英) McHeyzer-Williams MG (日) (読)
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| 6. | (英) Germain RN (日) (読)
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| 7. | (英) Ashwell JD (日) (読)
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| ○題名 (必須): | □ | (英) Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to "holes" in the T cell repertoire (日)
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| ○要約 (任意): | □ | (英) We have proposed that glucocorticoids antagonize TCR-mediated activation and influence which TCR avidities result in positive or negative selection. We now analyze the immune response of mice whose thymocytes express antisense transcripts to the glucocorticoid receptor (TKO mice). TKO mice responded normally to the complex antigen PPD but were proliferative nonresponders to pigeon cytochrome c 81-104 (PCC), having a large decrease in the frequency of PCC-responsive CD4+ T cells. Unlike wild-type T cells, few TKO T cells in PCC-specific cell lines expressed V alpha11+Vbeta3+. Furthermore, for naive CD4+ T cells from unimmunized TKO mice, the frequencies of many of the molecular features common to the CDR3 regions of PCC-responsive V alpha11+Vbeta3+ cells were substantially decreased. Thus, thymocyte glucocorticoid hyporesponsiveness resulted in loss of cells capable of responding to PCC, corresponding to an antigen-specific "hole" in the T cell repertoire. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) Cell Line (日) (読)
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| 3. | (英) Cytochrome c Group (日) (読)
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| 4. | (英) Female (日) (読)
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| 5. | (英) Glucocorticoids (日) (読)
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| 6. | (英) Male (日) (読)
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| 7. | (英) Mice (日) (読)
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| 8. | (英) Mice, Inbred C57BL (日) (読)
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| 9. | (英) Mice, Transgenic (日) (読)
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| 10. | (英) Receptors, Antigen, T-Cell, alpha-beta (日) (読)
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| 11. | (英) Receptors, Glucocorticoid (日) (読)
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| 12. | (英) T-Lymphocytes (日) (読)
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| 13. | (英) Thymus Gland (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Immunity (Cell Press)
(pISSN: 1074-7613, eISSN: 1097-4180)
| ○ISSN (任意): | □ | 1074-7613
ISSN: 1074-7613
(pISSN: 1074-7613, eISSN: 1097-4180) Title: ImmunityTitle(ISO): ImmunityPublisher: Cell Press (NLM Catalog)
(Scopus)
(CrossRef)
(Scopus information is found. [need login]) | [継承] |
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| ○巻 (必須): | □ | 12
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| ○号 (必須): | □ | 2
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| ○頁 (必須): | □ | 183 192
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| ○年月日 (必須): | □ | 西暦 2000年 2月 初日 (平成 12年 2月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/S1074-7613(00)80171-5 (→Scopusで検索)
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| ○PMID (任意): | □ | 10714684 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): | □ | 000085621400008
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| ○Scopus (任意): | □ | 2-s2.0-0034143917
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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