| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): | □ | Peer Review
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| ○カテゴリ (推奨): |
| ○共著種別 (推奨): |
| ○学究種別 (推奨): |
| ○組織 (推奨): |
| ○著者 (必須): | 1. | (英) Dorfman R. Jeffrey (日) (読)
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| ○学籍番号 (推奨): |
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| 2. | (英) Stefanova Irena (日) (読)
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| 3. | 安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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| ○学籍番号 (推奨): |
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| 4. | (英) Germain N. Ronald (日) (読)
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| ○題名 (必須): | □ | (英) CD4+ T-cell survival is not directly linked to self-MHC induced TCR signaling (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) T cell receptor (TCR) signaling triggered by recognition of self-major histocompatibility complex (MHC) ligands has been proposed to maintain the viability of naïve T cells and to provoke their proliferation in T cell-deficient hosts. Consistent with this, the partially phosphorylated state of TCR zeta chains in naïve CD4+ and CD8+ T cells in vivo was found to be actively maintained by TCR interactions with specific peptide-containing MHC molecules. TCR ligand-dependent phosphorylation of TCR zeta was lost within one day of cell transfer into MHC-deficient hosts, yet the survival of transferred CD4+ lymphocytes was the same in recipients with or without MHC class II expression for one month. Thus, despite clear evidence for TCR signaling in nonactivated naïve T cells, these data argue against the concept that such signaling plays a predominant role in determining lymphocyte lifespan. (日)
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| ○キーワード (推奨): | 1. | (英) Animals (日) (読)
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| 2. | (英) CD4-Positive T-Lymphocytes (日) (読)
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| 3. | (英) Cell Survival (日) (読)
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| 4. | (英) Lymphocyte Activation (日) (読)
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| 5. | (英) Major Histocompatibility Complex (日) (読)
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| 6. | (英) Membrane Proteins (日) (読)
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| 7. | (英) Mice (日) (読)
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| 8. | (英) Mice, Inbred C57BL (日) (読)
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| 9. | (英) Receptors, Antigen, T-Cell (日) (読)
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| 10. | (英) Signal Transduction (日) (読)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Nature Immunology ([Nature Publishing Group])
(pISSN: 1529-2908, eISSN: 1529-2916)
| ○ISSN (任意): | □ | 1529-2908
ISSN: 1529-2908
(pISSN: 1529-2908, eISSN: 1529-2916) Title: Nature immunologyTitle(ISO): Nat ImmunolPublisher: Nature Portfolio (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 1
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| ○号 (必須): | □ | 4
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| ○頁 (必須): | □ | 329 335
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 2000年 10月 初日 (平成 12年 10月 初日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1038/79783 (→Scopusで検索)
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| ○PMID (任意): | □ | 11017105 (→Scopusで検索)
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| ○備考 (任意): | 1. | (英) Article.Affiliation: Lymphocyte Biology Section, Laboratory of Immunology, Building 10 Room 11N311, National Institutes of Health, Bethesda, MD 20892, USA. (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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