『徳島大学 教育・研究者情報データベース (EDB)』---[学外] /
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EID=101377EID:101377, Map:0, LastModified:2012年8月31日(金) 18:04:05, Operator:[大家 隆弘], Avail:TRUE, Censor:0, Owner:[安友 康二], Read:継承, Write:継承, Delete:継承.
○種別 (必須): □学術論文 (審査論文) [継承]
○言語 (必須): □英語 [継承]
○招待 (推奨):
○審査 (推奨): □Peer Review [継承]
○カテゴリ (推奨):
○共著種別 (推奨):
○学究種別 (推奨):
○組織 (推奨):
○著者 (必須): 1.安友 康二 ([徳島大学.大学院医歯薬学研究部.医学域.医科学部門.病理系.生体防御医学])
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○学籍番号 (推奨):
[継承]
2. (英) Doyle C (日) (読)
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[継承]
3. (英) Miele L (日) (読)
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4. (英) Fuchs C (日) (読)
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5. (英) Germain RN (日) (読)
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[継承]
○題名 (必須): □(英) The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate  (日)    [継承]
○副題 (任意):
○要約 (任意): □(英) Signals elicited by binding of the T-cell antigen receptor and the CD4/CD8 co-receptor to major histocompatibility complex (MHC) molecules control the generation of CD4+ (helper) or CD8+ (cytotoxic) T cells from thymic precursors that initially express both co-receptor proteins. These precursors have unique, clonally distributed T-cell receptors with unpredictable specificity for the self-MHC molecules involved in this differentiation process. However, the mature T cells that emerge express only the CD4 (MHC class II-binding) or CD8 (MHC class I-binding) co-receptor that complements the MHC class-specificity of the T-cell receptor. How this matching of co-receptor-defined lineage and T-cell-receptor specificity is achieved remains unknown, as does whether signalling by the T-cell receptors, co-receptors and/or general cell-fate regulators such as Notch-1 contributes to initial lineage choice, to subsequent differentiation processes or to both. Here we show that the CD4 versus CD8 lineage fate of immature thymocytes is controlled by the co-receptor-influenced duration of initial T-cell receptor-dependent signalling. Notch-1 does not appear to be essential for this fate determination, but it is selectively required for CD8+ T-cell maturation after commitment directed by T-cell receptors. This indicates that the signals constraining CD4 versus CD8 lineage decisions are distinct from those that support subsequent differentiation events such as silencing of co-receptor loci.  (日)    [継承]
○キーワード (推奨): 1. (英) Animals (日) (読) [継承]
2. (英) Antigens, CD (日) (読) [継承]
3. (英) Antigens, CD4 (日) (読) [継承]
4. (英) Antigens, CD8 (日) (読) [継承]
5. (英) Antigens, Differentiation, T-Lymphocyte (日) (読) [継承]
6. (英) CD4-Positive T-Lymphocytes (日) (読) [継承]
7. (英) CD8-Positive T-Lymphocytes (日) (読) [継承]
8. (英) Cell Lineage (日) (読) [継承]
9. (英) Cells, Cultured (日) (読) [継承]
10. (英) Female (日) (読) [継承]
11. (英) Lectins, C-Type (日) (読) [継承]
12. (英) Leukopoiesis (日) (読) [継承]
13. (英) Ligands (日) (読) [継承]
14. (英) Major Histocompatibility Complex (日) (読) [継承]
15. (英) Male (日) (読) [継承]
16. (英) Membrane Proteins (日) (読) [継承]
17. (英) Mice (日) (読) [継承]
18. (英) Mice, Inbred C57BL (日) (読) [継承]
19. (英) Mice, Transgenic (日) (読) [継承]
20. (英) Models, Immunological (日) (読) [継承]
21. (英) Receptor, Notch1 (日) (読) [継承]
22. (英) Receptors, Antigen, T-Cell (日) (読) [継承]
23. (英) Receptors, Cell Surface (日) (読) [継承]
24. (英) Signal Transduction (日) (読) [継承]
25. (英) Thymus Gland (日) (読) [継承]
26. (英) Time Factors (日) (読) [継承]
27. (英) Transcription Factors (日) (読) [継承]
○発行所 (推奨):
○誌名 (必須): □Nature ([Nature Publishing Group])
(pISSN: 0028-0836, eISSN: 1476-4687)

○ISSN (任意): □0028-0836
ISSN: 0028-0836 (pISSN: 0028-0836, eISSN: 1476-4687)
Title: Nature
Title(ISO): Nature
Publisher: Nature Portfolio
 (NLM Catalog)   (Scopus)   (CrossRef)  (Scopus information is found. [need login])
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○巻 (必須): □404 [継承]
○号 (必須): □6777 [継承]
○頁 (必須): □506 510 [継承]
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○年月日 (必須): □西暦 2000年 3月 30日 (平成 12年 3月 30日) [継承]
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○DOI (任意): □10.1038/35006664    (→Scopusで検索) [継承]
○PMID (任意): □10761920    (→Scopusで検索) [継承]
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○備考 (任意): 1.(英) Article.Affiliation: Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.  (日)    [継承]
2.(英) Article.PublicationTypeList.PublicationType: Journal Article  (日)    [継承]
3.(英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't  (日)    [継承]
4.(英) Article.PublicationTypeList.PublicationType: Research Support, U.S. Gov't, P.H.S.  (日)    [継承]

標準的な表示

和文冊子 ● Koji Yasutomo, C Doyle, L Miele, C Fuchs and RN Germain : The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate, Nature, Vol.404, No.6777, 506-510, 2000.
欧文冊子 ● Koji Yasutomo, C Doyle, L Miele, C Fuchs and RN Germain : The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate, Nature, Vol.404, No.6777, 506-510, 2000.

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