| ○種別 (必須): | □ | 学術論文 (審査論文)
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| ○言語 (必須): | □ | 英語
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| ○招待 (推奨): |
| ○審査 (推奨): |
| ○カテゴリ (推奨): |
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| ○学究種別 (推奨): |
| ○組織 (推奨): | 1. | 徳島大学.大学院ヘルスバイオサイエンス研究部.生体システム栄養科学部門.摂食機能制御学講座 (2004年4月1日〜2015年3月31日)
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| 2. | 徳島大学.歯学部.歯学科
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| ○著者 (必須): | 1. | (英) Chen Cang (日) (読)
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| 2. | 石川 康子
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| 3. | (英) Amano Ichiro (日) 天野 伊知郎 (読) あまの いちろう
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| 4. | (英) Eguchi Takafumi (日) 江口 貴文 (読) えぐち たかふみ
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| 5. | (英) Ishida Hajime (日) 石田 甫 (読) いしだ はじめ
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| ○題名 (必須): | □ | (英) Age-dependent changes in response of rat prostatic tissues to isoproterenol and forskolin: changes with sexual maturation in function of G proteins. (日)
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| ○副題 (任意): |
| ○要約 (任意): | □ | (英) Developmental changes in the responses of rat ventral prostate to isoproterenol (IPR) and forskolin (F) were studied in relation to the function of beta-adrenoceptor-adenylate cyclase system. The response of adenylate cyclase in the tissues to IPR at 10(-7)M and above was steadily enhanced after birth and reached a maximum at 12 weeks, followed by a decrease with age. In contrast, the response of the enzyme to F at 10(-7)M and above was highest at 2 weeks, but thereafter decreased. The changes in the response of the enzyme to IPR coincided with changes in the beta-adrenoceptor density and the binding ability of GTP binding proteins (G proteins) to GTP. The ADP-ribosylation of inhibitory G proteins (Gi proteins) catalyzed by pertussis toxin (IAP) decreased 70% in the tissues from 4 to 8 weeks, and then maintained this level. On the other hand, the ADP-ribosylation of stimulatory G proteins (Gs proteins) catalyzed by cholera toxin (CT) increased only 20% in the tissues from 2 to 4 weeks. Thus, the ratio of ADP-ribosylation of Gs to that of Gi significantly increased from 4 weeks, reaching a maximum at 12 weeks, but thereafter decreased gradually with age. These changes paralleled those in the function of G proteins and the response of the enzyme to IPR. It is suggested that the rapid and marked decrease in apparent level of Gi proteins in the rat ventral prostate after 4 weeks may have a key role in controlling the function of the beta-adrenoceptor-adenylate cyclase system in the tissues. (日)
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| ○キーワード (推奨): | 1. | 細胞増殖·分化 (cell proliferation and differentiation)
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| 2. | 加齢変化 (aging patterrn)
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| 3. | 情報伝達機構 (signal transduction)
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| 4. | 神経伝達物質 (neurotransmitter)
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| ○発行所 (推奨): |
| ○誌名 (必須): | □ | Mechanisms of Ageing and Development (Elsevier Ireland Ltd)
(pISSN: 0047-6374, eISSN: 1872-6216)
| ○ISSN (任意): | □ | 0047-6374
ISSN: 0047-6374
(pISSN: 0047-6374, eISSN: 1872-6216) Title: Mechanisms of ageing and developmentTitle(ISO): Mech Ageing DevPublisher: Elsevier Ireland Ltd (NLM Catalog)
(Scopus)
(CrossRef)
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| ○巻 (必須): | □ | 81
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| ○号 (必須): | □ | 1
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| ○頁 (必須): | □ | 1 13
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| ○都市 (任意): |
| ○年月日 (必須): | □ | 西暦 1995年 6月 30日 (平成 7年 6月 30日)
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| ○URL (任意): |
| ○DOI (任意): | □ | 10.1016/0047-6374(94)01577-9 (→Scopusで検索)
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| ○PMID (任意): | □ | 7475348 (→Scopusで検索)
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| ○CRID (任意): |
| ○WOS (任意): |
| ○Scopus (任意): | □ | 2-s2.0-0029015938
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| ○評価値 (任意): |
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| ○指導教員 (推奨): |
| ○備考 (任意): | 1. | (英) Article.PublicationTypeList.PublicationType: Journal Article (日)
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| 2. | (英) Article.PublicationTypeList.PublicationType: Research Support, Non-U.S. Gov't (日)
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